Mucosal adjuvants

• Published in: Vaccine Vol. 23; no. 15; pp. 1804 - 1813
• Main Authors: Freytag, L.C., Clements, J.D.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Oxford Elsevier Ltd 07.03.2005; Elsevier; Elsevier Limited
• Subjects: Adenosine Diphosphate Ribose; Adjuvant; Adjuvants, Immunologic; Animals; Applied microbiology; Bacteria; Biological and medical sciences; CpG; Drug Synergism; Enterotoxin; Enterotoxins - pharmacology; Enterotoxins - toxicity; Escherichia coli; Fundamental and applied biological sciences. Psychology; Humans; Immune system; Immunity, Mucosal - immunology; Immunization; Kinases; Lipid A - analogs & derivatives; Lipid A - pharmacology; Lymphocytes; Microbiology; MPL; Oligodeoxyribonucleotides - pharmacology; Oral immunization; Rodents; Studies; Toxins; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Waterborne diseases; Enterotoxin; MPL; Adjuvant; CpG; Oral immunization; Toxin; Immunization; Immunological adjuvant; Mucosa; Vaccine

Induction of immune responses following oral immunization is frequently dependent upon the co-administration of appropriate adjuvants that can initiate and support the transition from innate to adaptive immunity. The three bacterial products with the greatest potential to function as mucosal adjuvan...