Endoplasmic reticulum stress may activate NLRP3 inflammasomes via TXNIP in preeclampsia

• Published in: Cell and tissue research Vol. 379; no. 3; pp. 589 - 599
• Main Authors: Yang, Yong, Li, Jianxin, Han, Ting-Li, Zhou, Xianbo, Qi, Hongbo, Baker, Philip N., Zhou, Wei, Zhang, Hua
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2020; Springer; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Caspase-1; Cell activation; domain; Endoplasmic reticulum; endoplasmic reticulum stress; Enzymatic activity; enzyme activity; family; Fetuses; Human Genetics; IL-1β; Immunoregulation; Inflammasomes; Inflammation; Interleukins; Lentivirus; Molecular Medicine; patients; Phenylbutyric acid; Placenta; Pre-eclampsia; Preeclampsia; protein content; Proteomics; Pyrin protein; Regular Article; siRNA; Thioredoxin; Tunicamycin; NLRP3; TXNIP; Preeclampsia (PE); Inflammation; Endoplasmic reticulum (ER) stress

Preeclampsia (PE) development is often associated with placental immune and inflammatory dysregulation, as well as endoplasmic reticulum (ER) stress. However, the mechanisms linking ER stress and inflammatory dysregulation to PE have not been elucidated. It has been reported that thioredoxin-interac...