Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions

• Published in: World journal of gastroenterology : WJG Vol. 22; no. 36; pp. 8078 - 8093
• Main Authors: Clemente, Maria Grazia, Mandato, Claudia, Poeta, Marco, Vajro, Pietro
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.09.2016
• Subjects: Adipose Tissue - metabolism; Anthropometry; Blood Pressure; Body Mass Index; Child; Child, Preschool; diagnosis; Diagnosis, Differential; disease; Disease Progression; disease;Childhood; Ethanol - chemistry; fatty; Fatty Liver - diagnosis; Fatty Liver - therapy; Gastrointestinal Microbiome; Humans; Infant; Infant, Newborn; Inflammation; Insulin Resistance; Intestines - metabolism; Life Style; liver; Liver - metabolism; Liver - pathology; metabolic; Micronutrients - metabolism; Non-alcoholic; Non-alcoholic Fatty Liver Disease - diagnosis; Non-alcoholic Fatty Liver Disease - therapy; Obesity; obesity;Non-alcoholic; Oxidative Stress; Pediatrics; Review; steatohepatitis;Hepatic; syndrome;Non-alcoholic; Vitamin D - metabolism; Waist Circumference; Non-alcoholic fatty liver disease diagnosis; Hepatic metabolic syndrome; Childhood obesity; Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis

Non-alcoholic fatty liver disease(NAFLD) in children is becoming a major health concern. A 'multiple-hit' pathogenetic model has been suggested to explain the progressive liver damage that occurs among children with NAFLD. In addition to the accumulation of fat in the liver, insuli...