Demographic and pathogen characteristics of incident bacterial meningitis in infants in South Africa: A cohort study

• Published in: PloS one Vol. 19; no. 9; p. e0310528
• Main Authors: Kiakuvue, Yannick Nkiambi, Mall, Sumaya, Govender, Nelesh, Gottberg, Anne von, Mashau, Rudzani, Meiring, Susan, Cohen, Cheryl
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 25.09.2024
• Subjects: Acinetobacter baumannii; Acinetobacter baumannii - isolation & purification; Acinetobacter baumannii - pathogenicity; Age; Age groups; Analysis; Bacteria; Bacteria, Pathogenic; Bacterial meningitis; Bacterial pneumonia; Biology and Life Sciences; Causes of; Cerebrospinal fluid; Children; Cohort Studies; Culture; Demographic aspects; Demographics; Demography; Diseases; Epidemics; Etiology; Female; Haemophilus influenzae; Haemophilus Vaccines; Humans; Hygiene; Identification and classification; Immunization; Incidence; Infant; Infant, Newborn; Infants; Infants (Newborn); Klebsiella; Klebsiella pneumoniae; Klebsiella pneumoniae - isolation & purification; Klebsiella pneumoniae - pathogenicity; Laboratories; Male; Medicine and Health Sciences; Meningitis; Meningitis, Bacterial - epidemiology; Meningitis, Bacterial - microbiology; Neonates; Nosocomial infection; Pathogens; Pediatric research; People and places; Pneumococcal Vaccines; Pneumonia; Population; Population studies; Risk assessment; South Africa - epidemiology; Statistics; Streptococcus infections; Streptococcus pneumoniae; Streptococcus pneumoniae - isolation & purification; Streptococcus pneumoniae - pathogenicity; Vaccination; Vaccines; Warehouse stores; South Africa; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0310528

Bacterial meningitis is a major cause of death, with an approximate case fatality rate of 37% across all age groups in South Africa. This study aimed to describe the demographic and pathogen characteristics of incident meningitis in children aged <1 year in South Africa from 2014 through 2018, during a period when Haemophilus influenzae type b vaccine and pneumococcal conjugate vaccines (PCV) were both included in the expanded program on immunization (EPI). We conducted a cohort study of routine laboratory data in the National Health Laboratory Service Corporate Data Warehouse, which covers approximately 80% of the South African population. We defined a case of laboratory-confirmed bacterial meningitis as any person aged <1 year with meningitis diagnosed by culture and identification of a pathogen documented as being a common cause of meningitis in CSF. The cause-specific incidence risks were calculated by dividing the number of positive specimens in each age group and year by the corresponding mid-year population for children under 1 year old and those in the post-neonatal period (≥ 28 days to 365 days old). For children under 28 days old, the annual numbers of registered livebirths were used. We used Poisson regression to compare the incidence of meningitis by year. We identified 3575 (1.5%) cases of culture-confirmed bacterial meningitis from the 232,016 cerebrospinal fluid (CSF) specimens tested from 2014-2018. The highest number of cases were recorded in children aged <28 days (1873, 52.4%), male children (1800, 50.4%) as well as in the Gauteng Province (2014, 56.3%). Acinetobacter baumannii (14.9%), followed by Klebsiella pneumoniae (13.5%), and group B streptococcus (GBS) (10.7%), were the most common pathogens detected. Overall, A. baumannii had the highest incidence risk, occurring at 9.8 per 100,000 persons in children aged <1 year in 2018. Among neonates, A. baumannii peaked at 14.9 per 100,000 livebirths in 2018, while Streptococcus pneumoniae was most common in the post-neonatal period (≥ 28 days to 365 days old), peaking at 9.8 per 100,000 persons in 2014. There was an increase in the annual incidence of most pathogens over the study period. There was an increasing trend in the annual incidence of bacterial meningitis in infants caused by most pathogens, particularly A. baumannii, K. pneumoniae and GBS. In addition to increased uptake of vaccination, prevention measures to reduce nosocomial and mother-to-child transmission of bacteria could include antenatal screening for GBS in pregnant women, rigorous hygiene in the hospital environment as well as rational antibiotic use.