Level and change in bone microarchitectural parameters and their relationship with previous fracture and established bone mineral density loci

• Published in: Bone (New York, N.Y.) Vol. 147; p. 115937
• Main Authors: Fuggle, Nicholas R., Westbury, Leo D., Bevilacqua, Gregorio, Titcombe, Philip, Ó Breasail, Mícheál, Harvey, Nicholas C., Dennison, Elaine M., Cooper, Cyrus, Ward, Kate A.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2021
• Subjects: Animals; Bone Density - genetics; Cohort Studies; Epidemiology; Female; Fracture; Fractures, Bone - diagnostic imaging; Fractures, Bone - genetics; Genome-Wide Association Study; Humans; Loci; Male; Mice; Osteoporosis; Quantitative computed tomography; Radius; Tibia; Osteoporosis; Fracture; Quantitative computed tomography; Epidemiology; Loci

Osteoporosis is characterised by a reduction of bone mineral density (BMD) and predisposition to fracture. Bone microarchitecture, measured by high resolution peripheral quantitative computed tomography (HR-pQCT), has been related to fragility fractures and BMD and has been the subject of large-scal...