Iron and non-alcoholic fatty liver disease

• Published in: World journal of gastroenterology : WJG Vol. 22; no. 36; pp. 8112 - 8122
• Main Authors: Britton, Laurence J, Subramaniam, V Nathan, Crawford, Darrell HG
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.09.2016
• Subjects: Adipose Tissue - metabolism; Animals; Endothelial Cells - cytology; Fatty Liver - metabolism; Ferritins - blood; Hepatocytes - metabolism; Homeostasis; Humans; Insulin Resistance; Iron - blood; Iron - metabolism; Iron;Fatty; Lipid Metabolism; Liver - metabolism; Liver - pathology; liver;Liver; mellitus;Adipose; Non-alcoholic Fatty Liver Disease - metabolism; Obesity - complications; resistance;Steatohepatitis;Diabetes; Review; steatosis;Insulin; tissue; Adipose tissue; Fatty liver; Diabetes mellitus; Steatohepatitis; Insulin resistance; Iron; Liver steatosis

The mechanisms that promote liver injury in non-alcoholic fatty liver disease(NAFLD) are yet to be thoroughly elucidated. As such, effective treatment strategies are lacking and novel therapeutic targets are required. Iron has been widely implicated in the pathogenesis of NAFLD and represents a pote...