The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 8; p. 1758
• Main Authors: Chellamuthu, Anitha, Gray, Steven G.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 22.07.2020; MDPI
• Subjects: 5-methylcytosine; 5-Methylcytosine - metabolism; Animals; Breast Neoplasms - enzymology; cancer; Carcinogenesis; Cell adhesion & migration; Cell cycle; Colorectal Neoplasms - enzymology; Deoxyribonucleic acid; DNA; DNA methylation; DNA methyltransferase; epi-transcriptome; Female; Gene expression; Genetic aspects; Health aspects; Humans; Lung Neoplasms - enzymology; Mammalian cells; Methylation; Methyltransferases; Methyltransferases - genetics; Methyltransferases - metabolism; Mice; miRNA; Mitochondria; mRNA; Neurological disorders; Non-small cell lung carcinoma; Phylogeny; Physiological aspects; Proteins; Review; RNA; RNA modification; RNA, Messenger - metabolism; Roles; Small cell lung carcinoma; Transfer RNA; Ireland; RNA modification; 5-methylcytosine; miRNA; cancer; mRNA; epi-transcriptome

5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreove...