The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer

5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreove...

Full description

Saved in:
Bibliographic Details
Published inCells (Basel, Switzerland) Vol. 9; no. 8; p. 1758
Main Authors Chellamuthu, Anitha, Gray, Steven G.
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 22.07.2020
MDPI
Subjects
5-methylcytosine
5-Methylcytosine - metabolism
Animals
Breast Neoplasms - enzymology
cancer
Carcinogenesis
Cell adhesion & migration
Cell cycle
Colorectal Neoplasms - enzymology
Deoxyribonucleic acid
DNA
DNA methylation
DNA methyltransferase
epi-transcriptome
Female
Gene expression
Genetic aspects
Health aspects
Humans
Lung Neoplasms - enzymology
Mammalian cells
Methylation
Methyltransferases
Methyltransferases - genetics
Methyltransferases - metabolism
Mice
miRNA
Mitochondria
mRNA
Neurological disorders
Non-small cell lung carcinoma
Phylogeny
Physiological aspects
Proteins
Review
RNA
RNA modification
RNA, Messenger - metabolism
Roles
Small cell lung carcinoma
Transfer RNA
Ireland
RNA modification
5-methylcytosine
miRNA
cancer
mRNA
epi-transcriptome
Online AccessGet full text

Cover

Abstract 5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreover, this modification can also be found in messenger RNAs and has led to an increasing appreciation that RNA methylation can functionally regulate gene expression and cellular activities. In mammalian cells, the addition of m5C to RNA cytosines is carried out by enzymes of the NOL1/NOP2/SUN domain (NSUN) family as well as the DNA methyltransferase homologue DNMT2. In this regard, NSUN2 is a critical RNA methyltransferase for adding m5C to mRNA. In this review, using non-small cell lung cancer and other cancers as primary examples, we discuss the recent developments in the known functions of this RNA methyltransferase and its potential critical role in cancer.
AbstractList 5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreover, this modification can also be found in messenger RNAs and has led to an increasing appreciation that RNA methylation can functionally regulate gene expression and cellular activities. In mammalian cells, the addition of m5C to RNA cytosines is carried out by enzymes of the NOL1/NOP2/SUN domain (NSUN) family as well as the DNA methyltransferase homologue DNMT2. In this regard, NSUN2 is a critical RNA methyltransferase for adding m5C to mRNA. In this review, using non-small cell lung cancer and other cancers as primary examples, we discuss the recent developments in the known functions of this RNA methyltransferase and its potential critical role in cancer.
5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreover, this modification can also be found in messenger RNAs and has led to an increasing appreciation that RNA methylation can functionally regulate gene expression and cellular activities. In mammalian cells, the addition of m5C to RNA cytosines is carried out by enzymes of the NOL1/NOP2/SUN domain (NSUN) family as well as the DNA methyltransferase homologue DNMT2. In this regard, NSUN2 is a critical RNA methyltransferase for adding m5C to mRNA. In this review, using non-small cell lung cancer and other cancers as primary examples, we discuss the recent developments in the known functions of this RNA methyltransferase and its potential critical role in cancer.5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly transfer RNAs, but increasingly found in cytoplasmic and mitochondrial ribosomal RNAs, enhancer RNAs, and a number of long noncoding RNAs. Moreover, this modification can also be found in messenger RNAs and has led to an increasing appreciation that RNA methylation can functionally regulate gene expression and cellular activities. In mammalian cells, the addition of m5C to RNA cytosines is carried out by enzymes of the NOL1/NOP2/SUN domain (NSUN) family as well as the DNA methyltransferase homologue DNMT2. In this regard, NSUN2 is a critical RNA methyltransferase for adding m5C to mRNA. In this review, using non-small cell lung cancer and other cancers as primary examples, we discuss the recent developments in the known functions of this RNA methyltransferase and its potential critical role in cancer.
Audience Academic
Author Chellamuthu, Anitha
Gray, Steven G.
AuthorAffiliation 2 Thoracic Oncology Research Group, St. James’s Hospital, Dublin D08 RX0X, Ireland
1 Department of Clinical Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland; chellama@tcd.ie
AuthorAffiliation_xml – name: 2 Thoracic Oncology Research Group, St. James’s Hospital, Dublin D08 RX0X, Ireland
– name: 1 Department of Clinical Medicine, Trinity College Dublin, Dublin D08 W9RT, Ireland; chellama@tcd.ie
Author_xml – sequence: 1
  givenname: Anitha
  surname: Chellamuthu
  fullname: Chellamuthu, Anitha
– sequence: 2
  givenname: Steven G.
  orcidid: 0000-0002-5850-6392
  surname: Gray
  fullname: Gray, Steven G.
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32708015$$D View this record in MEDLINE/PubMed
BookMark eNptkk1vGyEQhlGVqknT3HquVuqlh7jlc4FLJctqWkupW6XJGbEsa2NhSABXyr8vayeRE5ULCN555h1m3oKjEIMF4D2CnwmR8Iux3mcJBeJMvAInGHIyoRTKo4PzMTjLeQ3rEqhFkL0BxwRzKCBiJ2B6vbLN1WLa_LRlde9L0iEPNulsm8WfmwVudOibecnN71hsKE775ip6mxsXmpkOxqZ34PWgfbZnD_spuLn4dj37Mbn89X0-m15ODINtmXQdR4J02AjKZYdFdUeosALLjlAqra3eNB8oscj2hmItzIBqiQT2XIoeklMw33P7qNfqNrmNTvcqaqd2FzEtlU7FGW9Vh4QYetZ2NQklggnNSC_N0BtIkGlZZX3ds2633aamq5Ul7Z9Bn78Et1LL-Fdx2hLGcAV8egCkeLe1uaiNy2MzdLBxmxWmmGNJZcur9OML6TpuU6hftVPVTxhNPqmWuhbgwhBrXjNC1bSlECLR7nx_OPT9ZPixn1WA9wKTYs7JDsq4oouLYxnOKwTVODfqcG5q0PmLoEfuf-X_APFvwAo
CitedBy_id crossref_primary_10_3389_fonc_2022_851766
crossref_primary_10_52586_5016
crossref_primary_10_1007_s10142_024_01337_8
crossref_primary_10_3389_fimmu_2024_1362159
crossref_primary_10_1016_j_heliyon_2023_e19680
crossref_primary_10_1039_D2CB00243D
crossref_primary_10_3389_fgene_2022_864383
crossref_primary_10_1111_liv_15240
crossref_primary_10_1007_s00401_022_02511_7
crossref_primary_10_1016_j_ejmech_2024_116951
crossref_primary_10_1016_j_molmed_2022_09_007
crossref_primary_10_1017_erm_2021_4
crossref_primary_10_1038_s41598_023_41495_6
crossref_primary_10_1016_j_ijbiomac_2023_126773
crossref_primary_10_1016_j_redox_2024_103479
crossref_primary_10_1016_j_envint_2024_109055
crossref_primary_10_2174_1568009621666210127092828
crossref_primary_10_1007_s00277_023_05395_z
crossref_primary_10_1038_s41417_022_00533_7
crossref_primary_10_1016_j_jbo_2022_100448
crossref_primary_10_1038_s41698_025_00840_w
crossref_primary_10_1016_j_semcancer_2020_11_007
crossref_primary_10_3389_fcell_2021_718974
crossref_primary_10_3389_fgene_2022_972043
crossref_primary_10_3389_fimmu_2024_1512353
crossref_primary_10_3389_fgene_2022_816173
crossref_primary_10_3389_fgene_2022_960229
crossref_primary_10_1007_s10555_023_10163_6
crossref_primary_10_1016_j_abb_2025_110322
crossref_primary_10_1016_j_semcancer_2022_05_009
crossref_primary_10_1167_iovs_64_3_5
crossref_primary_10_1002_jcla_24303
crossref_primary_10_1080_22221751_2023_2178238
crossref_primary_10_3389_fonc_2023_1063636
crossref_primary_10_3390_genes12101488
crossref_primary_10_1007_s10495_022_01779_0
crossref_primary_10_1016_j_phrs_2024_107222
crossref_primary_10_1186_s13020_021_00501_7
crossref_primary_10_3389_fimmu_2023_1207371
crossref_primary_10_3233_CBM_210154
crossref_primary_10_1016_j_gendis_2025_101534
crossref_primary_10_3389_fcell_2022_885568
crossref_primary_10_1007_s11033_024_10138_y
crossref_primary_10_1111_bph_15604
crossref_primary_10_3390_curroncol30010044
crossref_primary_10_3389_fimmu_2021_800268
crossref_primary_10_1016_j_ecoenv_2024_117064
crossref_primary_10_3390_genes12050627
crossref_primary_10_3389_fphar_2022_984453
crossref_primary_10_1002_ange_202311924
crossref_primary_10_1016_j_heliyon_2021_e08519
crossref_primary_10_1016_j_ijbiomac_2023_127769
crossref_primary_10_1080_15476286_2024_2442856
crossref_primary_10_1038_s41598_024_52110_7
crossref_primary_10_3390_ijms23179740
crossref_primary_10_1016_j_abb_2021_109083
crossref_primary_10_1002_ctm2_1666
crossref_primary_10_1186_s40364_022_00362_8
crossref_primary_10_1016_j_cellsig_2024_111375
crossref_primary_10_7717_peerj_cs_1768
crossref_primary_10_3389_fonc_2022_965571
crossref_primary_10_1038_s41392_022_01175_9
crossref_primary_10_1080_08830185_2023_2280544
crossref_primary_10_3390_ijms24076520
crossref_primary_10_3389_fimmu_2024_1494873
crossref_primary_10_1038_s41420_024_02097_x
crossref_primary_10_1093_hmg_ddae106
crossref_primary_10_1016_j_prp_2023_154986
crossref_primary_10_3389_fcell_2022_915685
crossref_primary_10_1002_anie_202311924
crossref_primary_10_1002_ctm2_70239
crossref_primary_10_3389_fonc_2022_786266
crossref_primary_10_1002_jgm_70004
crossref_primary_10_1016_j_trecan_2023_04_003
crossref_primary_10_18632_aging_203203
crossref_primary_10_1016_j_molcel_2022_11_014
crossref_primary_10_3390_cells12081102
crossref_primary_10_1016_j_celrep_2024_114885
crossref_primary_10_3389_fgene_2022_894325
crossref_primary_10_1002_cbf_3996
crossref_primary_10_1016_j_ejphar_2025_177397
crossref_primary_10_1080_15384101_2023_2165632
crossref_primary_10_1021_acs_jmedchem_2c00388
crossref_primary_10_3389_fonc_2022_1055605
crossref_primary_10_1002_cam4_5500
crossref_primary_10_1111_jnc_16311
crossref_primary_10_1007_s11255_024_04214_2
crossref_primary_10_1016_j_gpb_2022_09_007
crossref_primary_10_1016_j_reth_2024_08_023
crossref_primary_10_3389_fphys_2021_729452
crossref_primary_10_1016_j_sbsr_2024_100690
crossref_primary_10_1038_s42004_025_01439_9
crossref_primary_10_1038_s41598_021_81971_5
crossref_primary_10_1038_s41598_023_30865_9
crossref_primary_10_1016_j_jbc_2024_106793
crossref_primary_10_1155_2021_3803724
crossref_primary_10_1038_s41417_024_00734_2
crossref_primary_10_1016_j_ijbiomac_2024_135817
crossref_primary_10_1016_j_tig_2022_10_004
crossref_primary_10_1093_stmcls_sxab024
crossref_primary_10_1016_j_cellsig_2023_110726
crossref_primary_10_1038_s41419_023_05646_x
crossref_primary_10_1080_10408363_2024_2370267
crossref_primary_10_1002_wrna_1700
crossref_primary_10_1016_j_ijbiomac_2023_128409
crossref_primary_10_1080_10408363_2021_2002256
crossref_primary_10_3389_fsurg_2022_948371
crossref_primary_10_3389_fcell_2022_841586
crossref_primary_10_1186_s12957_023_03067_w
crossref_primary_10_1016_j_sjbs_2021_09_017
crossref_primary_10_1186_s12967_023_04653_y
crossref_primary_10_3390_cancers13133372
crossref_primary_10_3389_fphar_2021_722728
crossref_primary_10_1016_j_cmet_2023_07_009
crossref_primary_10_1002_kjm2_12430
crossref_primary_10_1007_s13577_021_00583_3
crossref_primary_10_1038_s41419_023_05781_5
crossref_primary_10_1093_nar_gkab1148
crossref_primary_10_1186_s13104_022_05968_7
crossref_primary_10_1073_pnas_2317857121
crossref_primary_10_1038_s41388_023_02707_5
crossref_primary_10_3389_fgene_2024_1461386
crossref_primary_10_1002_mco2_70042
crossref_primary_10_3389_fonc_2025_1534948
crossref_primary_10_1089_omi_2025_0025
crossref_primary_10_1038_s12276_024_01184_4
crossref_primary_10_3389_fonc_2021_633415
crossref_primary_10_15252_embr_202356808
crossref_primary_10_1016_j_biopha_2022_113956
crossref_primary_10_3390_cancers15235614
crossref_primary_10_1186_s12943_024_02041_8
crossref_primary_10_1002_ame2_12221
crossref_primary_10_1155_2021_6173206
Cites_doi 10.1016/j.bbagrm.2018.10.014
10.1016/j.lfs.2019.117034
10.1038/s41556-019-0319-0
10.1186/s13059-016-1139-1
10.1016/j.toxlet.2015.01.019
10.1111/cas.14190
10.1093/nar/27.15.3138
10.1016/j.jbior.2017.10.005
10.1158/0008-5472.CAN-07-1076
10.1371/journal.pone.0191325
10.1038/s41556-019-0361-y
10.1111/cas.14006
10.1038/nsmb.1838
10.2217/fon-2017-0084
10.1002/wrna.1380
10.1158/2159-8290.CD-13-0358
10.1016/j.stemcr.2016.11.014
10.1093/nar/gkz575
10.1158/2159-8290.CD-12-0095
10.1016/j.jalz.2019.06.4891
10.1016/j.sbi.2012.04.002
10.1158/1078-0432.CCR-10-2542
10.1126/scisignal.2004088
10.1101/gr.210666.116
10.1038/s41467-018-04518-9
10.1016/j.ceb.2014.06.006
10.1371/journal.pgen.1002403
10.1093/hmg/ddz274
10.2217/epi-2018-0169
10.1016/j.neuron.2018.07.009
10.3389/fphar.2019.00303
10.1038/nature11112
10.3389/fnins.2020.00098
10.1002/wrna.1510
10.1038/s41593-017-0057-1
10.2217/epi-2019-0148
10.1111/jcmm.15101
10.1091/mbc.e06-11-1021
10.1016/j.gpb.2018.12.007
10.1038/s41467-019-10020-7
10.1093/bioinformatics/btt710
10.1038/d41573-019-00179-5
10.1016/j.oraloncology.2019.104554
10.1098/rsob.190307
10.1182/blood-2017-12-818948
10.1016/j.bbrc.2017.09.069
10.1002/jcb.25957
10.1016/j.canlet.2009.08.004
10.1074/jbc.M115.667717
10.1038/nature18282
10.1016/0092-8674(76)90022-2
10.1038/s41419-020-2487-z
10.1093/nar/gkx934
10.1038/ncomms1692
10.1016/j.cell.2019.01.030
10.1126/science.1120976
10.1186/1755-8794-6-35
10.1016/j.cell.2017.09.003
10.21037/atm.2018.12.13
10.18632/oncotarget.5302
10.1038/nbt.2566
10.1371/journal.pgen.1004639
10.1038/s41422-018-0092-9
10.1371/journal.pone.0082241
10.1038/s41593-019-0339-x
10.1093/nar/gks144
10.1038/cr.2017.143
10.1128/MCB.01523-12
10.1038/nprot.2014.014
10.1093/nar/gkz559
10.1523/JNEUROSCI.4053-15.2016
10.1083/jcb.200810180
10.1038/nsmb.3162
10.1007/s12031-015-0592-8
10.1200/JCO.1999.17.9.2721
10.1186/s13059-018-1436-y
10.3390/biom10040614
10.1007/s11684-019-0694-8
10.1371/journal.pgen.1003602
10.1126/science.1090095
10.18632/aging.100860
10.1016/j.cub.2006.04.027
10.1158/1541-7786.MCR-10-0242
10.3791/61231
10.1016/j.canlet.2018.05.013
10.1161/CIRCRESAHA.115.307674
10.3390/genes10020102
10.3390/pharmaceutics11070300
10.1128/MCB.00243-14
10.1038/cr.2017.55
10.21037/atm.2019.12.65
10.1093/nar/2.10.1653
10.1007/s00432-002-0386-6
10.1038/ncomms8030
10.1093/nar/gkx1030
10.1023/A:1011617707999
10.1038/s41419-020-2555-4
10.1038/nsmb.2357
10.1158/1535-7163.MCT-19-0690
10.3389/fmolb.2017.00038
10.1128/MCB.00742-15
10.3389/fonc.2020.00289
10.18632/oncotarget.8087
10.1016/j.ymeth.2018.10.013
10.3390/molecules24244492
10.1101/gad.586710
10.1016/j.gep.2013.06.003
10.15252/embj.201489282
10.18632/oncotarget.10612
10.1080/07357907.2018.1466896
10.1016/j.neo.2017.05.002
10.1016/j.cell.2012.05.003
10.1016/j.semcdb.2019.05.028
10.1038/s41588-019-0433-8
10.1016/j.tig.2019.10.011
10.1186/s12915-020-00769-5
10.1080/15476286.2019.1708549
10.1038/s41467-019-12651-2
10.1111/cge.12280
10.1038/s41388-018-0588-2
10.1073/pnas.71.10.3971
10.1016/j.ajhg.2012.03.021
10.1016/j.canlet.2014.09.007
10.1158/1078-0432.CCR-04-2135
10.1093/molbev/msy096
10.1038/s41586-018-0666-1
10.1371/journal.pone.0015145
10.1016/j.neuron.2018.06.007
10.1016/S0021-9258(18)69432-3
10.1016/j.ccr.2011.12.029
10.1089/dna.2011.1446
10.1016/j.bbrc.2019.09.098
10.1136/jmedgenet-2011-100686
10.1038/nrd2180
10.1016/j.pharmthera.2018.10.011
10.1038/s41568-020-0253-2
10.1016/j.celrep.2013.06.029
10.1186/s12967-020-02417-6
10.1016/j.ajhg.2012.03.023
ContentType Journal Article
Copyright COPYRIGHT 2020 MDPI AG
2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2020 by the authors. 2020
Copyright_xml – notice: COPYRIGHT 2020 MDPI AG
– notice: 2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2020 by the authors. 2020
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
8FD
8FE
8FH
ABUWG
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
CCPQU
DWQXO
FR3
GNUQQ
HCIFZ
LK8
M7P
P64
PHGZM
PHGZT
PIMPY
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
DOA
DOI 10.3390/cells9081758
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Central (Alumni)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
ProQuest One Community College
ProQuest Central Korea
Engineering Research Database
ProQuest Central Student
SciTech Premium Collection
ProQuest Biological Science Collection
Biological Science Database
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
Publicly Available Content Database
ProQuest One Academic Middle East (New)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Central Essentials
ProQuest Central (Alumni Edition)
SciTech Premium Collection
ProQuest One Community College
ProQuest Natural Science Collection
ProQuest Central China
ProQuest Central
ProQuest One Applied & Life Sciences
Genetics Abstracts
Natural Science Collection
ProQuest Central Korea
Biological Science Collection
ProQuest Central (New)
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
Biological Science Database
ProQuest SciTech Collection
Biotechnology and BioEngineering Abstracts
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
ProQuest One Academic (New)
MEDLINE - Academic
DatabaseTitleList MEDLINE


MEDLINE - Academic
CrossRef
Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2073-4409
ExternalDocumentID oai_doaj_org_article_b188fd56b07343858a53d9cfdc031c65
PMC7463552
A640018665
32708015
10_3390_cells9081758
Genre Journal Article
Review
GeographicLocations Ireland
GeographicLocations_xml – name: Ireland
GroupedDBID 53G
5VS
8FE
8FH
AADQD
AAFWJ
AAYXX
ABDBF
ACUHS
ADBBV
AFKRA
AFPKN
AFZYC
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BBNVY
BCNDV
BENPR
BHPHI
CCPQU
CITATION
DIK
EBD
ESX
GROUPED_DOAJ
HCIFZ
HYE
IAO
IHR
KQ8
LK8
M48
M7P
MODMG
M~E
OK1
PGMZT
PHGZM
PHGZT
PIMPY
PROAC
RPM
CGR
CUY
CVF
ECM
EIF
NPM
8FD
ABUWG
AZQEC
DWQXO
FR3
GNUQQ
P64
PKEHL
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c506t-bb7183b2c8479b28073348e829b3449ee161a7f43e1edc42a8cf139030d798d03
IEDL.DBID M48
ISSN 2073-4409
IngestDate Wed Aug 27 01:23:44 EDT 2025
Thu Aug 21 13:55:25 EDT 2025
Thu Jul 10 16:38:53 EDT 2025
Fri Jul 25 11:59:51 EDT 2025
Tue Jun 17 21:31:12 EDT 2025
Thu Apr 03 06:56:34 EDT 2025
Thu Apr 24 22:53:25 EDT 2025
Tue Jul 01 01:06:06 EDT 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 8
Keywords RNA modification
5-methylcytosine
miRNA
cancer
mRNA
epi-transcriptome
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c506t-bb7183b2c8479b28073348e829b3449ee161a7f43e1edc42a8cf139030d798d03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-5850-6392
OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.3390/cells9081758
PMID 32708015
PQID 2427348734
PQPubID 2032536
ParticipantIDs doaj_primary_oai_doaj_org_article_b188fd56b07343858a53d9cfdc031c65
pubmedcentral_primary_oai_pubmedcentral_nih_gov_7463552
proquest_miscellaneous_2427294967
proquest_journals_2427348734
gale_infotracmisc_A640018665
pubmed_primary_32708015
crossref_citationtrail_10_3390_cells9081758
crossref_primary_10_3390_cells9081758
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-07-22
PublicationDateYYYYMMDD 2020-07-22
PublicationDate_xml – month: 07
  year: 2020
  text: 2020-07-22
  day: 22
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Cells (Basel, Switzerland)
PublicationTitleAlternate Cells
PublicationYear 2020
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References Chi (ref_43) 2013; 13
Okamoto (ref_93) 2012; 31
Shinoda (ref_74) 2019; 47
Cai (ref_114) 2019; 38
ref_132
Lee (ref_33) 2019; 47
Zhang (ref_69) 2018; 28
Greene (ref_99) 2017; 4
Fedele (ref_101) 1996; 56
Yang (ref_36) 2017; 27
Sajini (ref_40) 2019; 10
Li (ref_64) 2018; 19
ref_18
Sato (ref_106) 1999; 17
ref_17
Kumar (ref_29) 2018; 35
Stein (ref_145) 2018; 131
Tuorto (ref_52) 2012; 19
Meyer (ref_10) 2012; 149
Yi (ref_97) 2017; 8
Hussain (ref_23) 2013; 4
Li (ref_6) 2019; 22
Li (ref_35) 2018; 430
Lence (ref_63) 2019; 1862
Manning (ref_98) 2020; 17
ref_126
ref_125
Shah (ref_30) 2014; 30
ref_128
Gong (ref_135) 2017; 21
Kim (ref_82) 2019; 15
Zarnack (ref_22) 2010; 17
Wang (ref_85) 2020; 24
Cohn (ref_1) 1960; 235
Blanco (ref_41) 2014; 33
ref_26
Lu (ref_118) 2018; 36
Legrand (ref_25) 2017; 27
Xu (ref_133) 2020; 14
Goll (ref_27) 2006; 311
Komara (ref_79) 2015; 57
Uchiyama (ref_107) 1997; 3
Cui (ref_137) 2020; 11
Shibata (ref_139) 2020; 19
Horos (ref_130) 2019; 176
Tsai (ref_143) 2012; 21
Lv (ref_84) 2018; 28
Cao (ref_60) 2020; 29
Frye (ref_92) 2006; 16
Yoon (ref_68) 2017; 171
Martinez (ref_77) 2012; 49
Wang (ref_51) 2017; 493
Ule (ref_21) 2003; 302
Kuwano (ref_138) 2019; 110
Gao (ref_112) 2013; 6
Desrosiers (ref_7) 1974; 71
Zhang (ref_46) 2012; 3
Trixl (ref_2) 2019; 10
Dai (ref_134) 2015; 6
Xuan (ref_4) 2018; 46
Dominissini (ref_9) 2012; 485
Saijo (ref_105) 2001; 12
Alshaker (ref_122) 2020; 10
Freeman (ref_104) 1988; 48
ref_146
Squires (ref_15) 2012; 40
Xing (ref_55) 2015; 35
Mei (ref_54) 2020; 11
Widagdo (ref_67) 2016; 36
Li (ref_57) 2017; 118
Mertel (ref_72) 2012; 90
Bader (ref_76) 2020; 99
Yang (ref_117) 2017; 13
Kaminskas (ref_141) 2005; 11
Hussain (ref_39) 2009; 186
Steinhardt (ref_144) 2013; 3
Reid (ref_28) 1999; 27
Zheng (ref_124) 2019; 195
Chen (ref_87) 2019; 239
Delaunay (ref_90) 2019; 21
Lewinska (ref_88) 2015; 233
Luo (ref_89) 2016; 118
Barbieri (ref_91) 2020; 20
Yang (ref_59) 2015; 290
Sun (ref_34) 2019; 11
Kanungo (ref_75) 2018; 6
Tang (ref_56) 2015; 7
Jelinek (ref_13) 1976; 7
Cai (ref_50) 2016; 7
Engel (ref_61) 2018; 99
Koranda (ref_62) 2018; 99
He (ref_86) 2019; 7
Huang (ref_11) 2020; 36
Doan (ref_78) 2019; 51
Li (ref_103) 2014; 355
Gao (ref_120) 2019; 110
Hussain (ref_44) 2013; 33
Sun (ref_49) 2019; 19
Chen (ref_47) 2019; 21
Han (ref_71) 2020; 14
Gopinath (ref_131) 2010; 8
Amort (ref_14) 2017; 18
Khoddami (ref_24) 2013; 31
Chen (ref_100) 2019; 10
Chen (ref_70) 2019; 17
Amort (ref_127) 2015; 6
ref_115
Blanco (ref_38) 2014; 31
Shi (ref_65) 2018; 563
ref_32
Wang (ref_102) 2011; 17
Cerami (ref_111) 2012; 2
ref_113
Horos (ref_129) 2020; 10
Khoddami (ref_20) 2014; 9
Wang (ref_66) 2018; 21
Boccaletto (ref_3) 2018; 46
Schaefer (ref_73) 2010; 24
Wang (ref_53) 2016; 7
Alshaker (ref_123) 2019; 10
Dubin (ref_12) 1975; 2
Kanda (ref_58) 2007; 18
Lu (ref_119) 2020; 101
Jones (ref_31) 1992; 8
Yuan (ref_48) 2014; 34
Korlach (ref_5) 2012; 22
Khan (ref_81) 2012; 90
Chandrashekar (ref_94) 2017; 19
ref_108
Yahata (ref_136) 2002; 128
Vachon (ref_96) 2007; 67
ref_109
Zhang (ref_19) 2020; 18
Wu (ref_83) 2019; 11
ref_45
Liu (ref_8) 2016; 23
Cheng (ref_110) 2018; 9
Fahiminiya (ref_80) 2014; 86
Bormann (ref_16) 2019; 156
Gore (ref_142) 2006; 5
Frye (ref_95) 2010; 289
Xue (ref_37) 2019; 520
Geffken (ref_121) 2018; 67
Blanco (ref_116) 2016; 534
Flores (ref_42) 2017; 8
Cully (ref_140) 2019; 18
References_xml – volume: 1862
  start-page: 222
  year: 2019
  ident: ref_63
  article-title: Mechanistic insights into m(6)A RNA enzymes
  publication-title: Biochim Biophys Acta Gene Regul. Mech.
  doi: 10.1016/j.bbagrm.2018.10.014
– volume: 239
  start-page: 117034
  year: 2019
  ident: ref_87
  article-title: METTL14-dependent m6A regulates vascular calcification induced by indoxyl sulfate
  publication-title: Life Sci.
  doi: 10.1016/j.lfs.2019.117034
– volume: 21
  start-page: 552
  year: 2019
  ident: ref_90
  article-title: RNA modifications regulating cell fate in cancer
  publication-title: Nat. Cell Biol
  doi: 10.1038/s41556-019-0319-0
– volume: 18
  start-page: 1
  year: 2017
  ident: ref_14
  article-title: Distinct 5-methylcytosine profiles in poly(A) RNA from mouse embryonic stem cells and brain
  publication-title: Genome Biol.
  doi: 10.1186/s13059-016-1139-1
– volume: 233
  start-page: 227
  year: 2015
  ident: ref_88
  article-title: Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells
  publication-title: Toxicol. Lett.
  doi: 10.1016/j.toxlet.2015.01.019
– volume: 3
  start-page: 1873
  year: 1997
  ident: ref_107
  article-title: Expression of nucleolar protein p120 in human lung cancer: Difference in histological types as a marker for proliferation
  publication-title: Clin. Cancer Res.
– volume: 110
  start-page: 3510
  year: 2019
  ident: ref_120
  article-title: NOP2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL6 in gallbladder carcinoma
  publication-title: Cancer Sci.
  doi: 10.1111/cas.14190
– volume: 27
  start-page: 3138
  year: 1999
  ident: ref_28
  article-title: Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/27.15.3138
– volume: 67
  start-page: 59
  year: 2018
  ident: ref_121
  article-title: Sphingosine kinase 1 in breast cancer
  publication-title: Adv. Biol Regul
  doi: 10.1016/j.jbior.2017.10.005
– volume: 67
  start-page: 8412
  year: 2007
  ident: ref_96
  article-title: Strong evidence of a genetic determinant for mammographic density, a major risk factor for breast cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-1076
– ident: ref_132
  doi: 10.1371/journal.pone.0191325
– volume: 21
  start-page: 978
  year: 2019
  ident: ref_47
  article-title: 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs
  publication-title: Nat. Cell Biol.
  doi: 10.1038/s41556-019-0361-y
– volume: 110
  start-page: 1536
  year: 2019
  ident: ref_138
  article-title: Oncogenic Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer
  publication-title: Cancer Sci.
  doi: 10.1111/cas.14006
– volume: 17
  start-page: 909
  year: 2010
  ident: ref_22
  article-title: iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.1838
– volume: 13
  start-page: 1981
  year: 2017
  ident: ref_117
  article-title: Association of tRNA methyltransferase NSUN2/IGF-II molecular signature with ovarian cancer survival
  publication-title: Future Oncol.
  doi: 10.2217/fon-2017-0084
– volume: 7
  start-page: 838
  year: 2016
  ident: ref_53
  article-title: mRNA methylation by NSUN2 in cell proliferation
  publication-title: Wiley Interdiscip Rev. RNA
  doi: 10.1002/wrna.1380
– volume: 3
  start-page: 968
  year: 2013
  ident: ref_144
  article-title: Epigenetic approaches for chemosensitization of refractory diffuse large B-cell lymphomas
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-13-0358
– volume: 8
  start-page: 112
  year: 2017
  ident: ref_42
  article-title: Cytosine-5 RNA Methylation Regulates Neural Stem Cell Differentiation and Motility
  publication-title: Stem Cell Rep.
  doi: 10.1016/j.stemcr.2016.11.014
– volume: 47
  start-page: 8734
  year: 2019
  ident: ref_74
  article-title: Mammalian NSUN2 introduces 5-methylcytidines into mitochondrial tRNAs
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz575
– volume: 2
  start-page: 401
  year: 2012
  ident: ref_111
  article-title: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-12-0095
– volume: 15
  start-page: P1642
  year: 2019
  ident: ref_82
  article-title: O5-10-04: dysregulation of nsun2 promotes pathological tau alterations in alzheimer’s disease
  publication-title: Alzheimer’s & Dementia
  doi: 10.1016/j.jalz.2019.06.4891
– volume: 22
  start-page: 251
  year: 2012
  ident: ref_5
  article-title: Going beyond five bases in DNA sequencing
  publication-title: Curr. Opin. Struct. Biol.
  doi: 10.1016/j.sbi.2012.04.002
– volume: 17
  start-page: 2570
  year: 2011
  ident: ref_102
  article-title: Overexpression of HMGA2 promotes metastasis and impacts survival of colorectal cancers
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-10-2542
– volume: 6
  start-page: pl1
  year: 2013
  ident: ref_112
  article-title: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
  publication-title: Sci. Signal.
  doi: 10.1126/scisignal.2004088
– volume: 27
  start-page: 1589
  year: 2017
  ident: ref_25
  article-title: Statistically robust methylation calling for whole-transcriptome bisulfite sequencing reveals distinct methylation patterns for mouse RNAs
  publication-title: Genome Res.
  doi: 10.1101/gr.210666.116
– volume: 9
  start-page: 2286
  year: 2018
  ident: ref_110
  article-title: Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-018-04518-9
– volume: 31
  start-page: 1
  year: 2014
  ident: ref_38
  article-title: Role of RNA methyltransferases in tissue renewal and pathology
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2014.06.006
– ident: ref_45
  doi: 10.1371/journal.pgen.1002403
– volume: 29
  start-page: 727
  year: 2020
  ident: ref_60
  article-title: Dynamic effects of Fto in regulating the proliferation and differentiation of adult neural stem cells of mice
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddz274
– volume: 11
  start-page: 439
  year: 2019
  ident: ref_34
  article-title: Effects of NSUN2 deficiency on the mRNA 5-methylcytosine modification and gene expression profile in HEK293 cells
  publication-title: Epigenomics
  doi: 10.2217/epi-2018-0169
– volume: 99
  start-page: 389
  year: 2018
  ident: ref_61
  article-title: The Role of m(6)A/m-RNA Methylation in Stress Response Regulation
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.07.009
– volume: 10
  start-page: 303
  year: 2019
  ident: ref_123
  article-title: Transcriptome-Wide Effects of Sphingosine Kinases Knockdown in Metastatic Prostate and Breast Cancer Cells: Implications for Therapeutic Targeting
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2019.00303
– volume: 485
  start-page: 201
  year: 2012
  ident: ref_9
  article-title: Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq
  publication-title: Nature
  doi: 10.1038/nature11112
– volume: 14
  start-page: 98
  year: 2020
  ident: ref_71
  article-title: Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2020.00098
– volume: 10
  start-page: e1510
  year: 2019
  ident: ref_2
  article-title: The dynamic RNA modification 5-methylcytosine and its emerging role as an epitranscriptomic mark
  publication-title: Wiley Interdiscip. Rev. RNA
  doi: 10.1002/wrna.1510
– volume: 21
  start-page: 195
  year: 2018
  ident: ref_66
  article-title: N(6)-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-017-0057-1
– volume: 11
  start-page: 1359
  year: 2019
  ident: ref_83
  article-title: Epitranscriptomic mechanisms of N6-methyladenosine methylation regulating mammalian hypertension development by determined spontaneously hypertensive rats pericytes
  publication-title: Epigenomics
  doi: 10.2217/epi-2019-0148
– volume: 24
  start-page: 4981
  year: 2020
  ident: ref_85
  article-title: Wilms’ tumour 1-associating protein inhibits endothelial cell angiogenesis by m6A-dependent epigenetic silencing of desmoplakin in brain arteriovenous malformation
  publication-title: J. Cell Mol. Med.
  doi: 10.1111/jcmm.15101
– volume: 18
  start-page: 1107
  year: 2007
  ident: ref_58
  article-title: Aurora-B regulates RNA methyltransferase NSUN2
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e06-11-1021
– volume: 17
  start-page: 154
  year: 2019
  ident: ref_70
  article-title: m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
  publication-title: Genom. Proteom. Bioinform.
  doi: 10.1016/j.gpb.2018.12.007
– volume: 10
  start-page: 2550
  year: 2019
  ident: ref_40
  article-title: Loss of 5-methylcytosine alters the biogenesis of vault-derived small RNAs to coordinate epidermal differentiation
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10020-7
– volume: 30
  start-page: 590
  year: 2014
  ident: ref_30
  article-title: ChromoHub V2: Cancer genomics
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btt710
– volume: 18
  start-page: 892
  year: 2019
  ident: ref_140
  article-title: Chemical inhibitors make their RNA epigenetic mark
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/d41573-019-00179-5
– volume: 101
  start-page: 104554
  year: 2020
  ident: ref_119
  article-title: Transfer RNA methyltransferase gene NSUN2 mRNA expression modifies the effect of T cell activation score on patient survival in head and neck squamous carcinoma
  publication-title: Oral Oncol.
  doi: 10.1016/j.oraloncology.2019.104554
– volume: 10
  start-page: 190307
  year: 2020
  ident: ref_129
  article-title: ‘High vault-age’: Non-coding RNA control of autophagy
  publication-title: Open Biol.
  doi: 10.1098/rsob.190307
– volume: 131
  start-page: 2661
  year: 2018
  ident: ref_145
  article-title: The DOT1L inhibitor pinometostat reduces H3K79 methylation and has modest clinical activity in adult acute leukemia
  publication-title: Blood
  doi: 10.1182/blood-2017-12-818948
– volume: 493
  start-page: 94
  year: 2017
  ident: ref_51
  article-title: Homocysteine upregulates interleukin-17A expression via NSun2-mediated RNA methylation in T lymphocytes
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2017.09.069
– volume: 118
  start-page: 2587
  year: 2017
  ident: ref_57
  article-title: NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation
  publication-title: J. Cell Biochem.
  doi: 10.1002/jcb.25957
– volume: 289
  start-page: 71
  year: 2010
  ident: ref_95
  article-title: Genomic gain of 5p15 leads to over-expression of Misu (NSUN2) in breast cancer
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2009.08.004
– volume: 290
  start-page: 26627
  year: 2015
  ident: ref_59
  article-title: Proteinase-activated receptor 2 promotes cancer cell migration through RNA methylation-mediated repression of miR-125b
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.667717
– volume: 534
  start-page: 335
  year: 2016
  ident: ref_116
  article-title: Stem cell function and stress response are controlled by protein synthesis
  publication-title: Nature
  doi: 10.1038/nature18282
– volume: 7
  start-page: 227
  year: 1976
  ident: ref_13
  article-title: Methyl labeling of HeLa cell hnRNA: A comparison with mRNA
  publication-title: Cell
  doi: 10.1016/0092-8674(76)90022-2
– volume: 11
  start-page: 270
  year: 2020
  ident: ref_54
  article-title: RNA methyltransferase NSUN2 promotes gastric cancer cell proliferation by repressing p57(Kip2) by an m(5)C-dependent manner
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-2487-z
– volume: 46
  start-page: D327
  year: 2018
  ident: ref_4
  article-title: RMBase v2.0: Deciphering the map of RNA modifications from epitranscriptome sequencing data
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx934
– volume: 3
  start-page: 712
  year: 2012
  ident: ref_46
  article-title: The tRNA methyltransferase NSun2 stabilizes p16INK4 mRNA by methylating the 3′-untranslated region of p16
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms1692
– volume: 176
  start-page: 1054
  year: 2019
  ident: ref_130
  article-title: The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy
  publication-title: Cell
  doi: 10.1016/j.cell.2019.01.030
– volume: 311
  start-page: 395
  year: 2006
  ident: ref_27
  article-title: Methylation of tRNAAsp by the DNA methyltransferase homolog Dnmt2
  publication-title: Science
  doi: 10.1126/science.1120976
– ident: ref_108
  doi: 10.1186/1755-8794-6-35
– volume: 171
  start-page: 877
  year: 2017
  ident: ref_68
  article-title: Temporal Control of Mammalian Cortical Neurogenesis by m(6)A Methylation
  publication-title: Cell
  doi: 10.1016/j.cell.2017.09.003
– volume: 6
  start-page: 475
  year: 2018
  ident: ref_75
  article-title: Mitochondrial disorders
  publication-title: Ann. Transl. Med.
  doi: 10.21037/atm.2018.12.13
– volume: 6
  start-page: 33878
  year: 2015
  ident: ref_134
  article-title: BPTF promotes tumor growth and predicts poor prognosis in lung adenocarcinomas
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.5302
– volume: 31
  start-page: 458
  year: 2013
  ident: ref_24
  article-title: Identification of direct targets and modified bases of RNA cytosine methyltransferases
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.2566
– volume: 21
  start-page: 102
  year: 2017
  ident: ref_135
  article-title: BPTF biomarker correlates with poor survival in human NSCLC
  publication-title: Eur Rev. Med. Pharmacol. Sci.
– ident: ref_125
  doi: 10.1371/journal.pgen.1004639
– volume: 28
  start-page: 1050
  year: 2018
  ident: ref_69
  article-title: METTL3-mediated N(6)-methyladenosine mRNA modification enhances long-term memory consolidation
  publication-title: Cell Res.
  doi: 10.1038/s41422-018-0092-9
– ident: ref_115
  doi: 10.1371/journal.pone.0082241
– volume: 22
  start-page: 534
  year: 2019
  ident: ref_6
  article-title: The DNA modification N6-methyl-2′-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction
  publication-title: Nat. Neurosci.
  doi: 10.1038/s41593-019-0339-x
– volume: 40
  start-page: 5023
  year: 2012
  ident: ref_15
  article-title: Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gks144
– volume: 28
  start-page: 249
  year: 2018
  ident: ref_84
  article-title: Endothelial-specific m(6)A modulates mouse hematopoietic stem and progenitor cell development via Notch signaling
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.143
– volume: 33
  start-page: 1561
  year: 2013
  ident: ref_44
  article-title: The mouse cytosine-5 RNA methyltransferase NSun2 is a component of the chromatoid body and required for testis differentiation
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.01523-12
– volume: 48
  start-page: 1244
  year: 1988
  ident: ref_104
  article-title: Identification and characterization of a human proliferation-associated nucleolar antigen with a molecular weight of 120,000 expressed in early G1 phase
  publication-title: Cancer Res.
– volume: 9
  start-page: 337
  year: 2014
  ident: ref_20
  article-title: Transcriptome-wide target profiling of RNA cytosine methyltransferases using the mechanism-based enrichment procedure Aza-IP
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2014.014
– volume: 47
  start-page: 8720
  year: 2019
  ident: ref_33
  article-title: NSUN2 introduces 5-methylcytosines in mammalian mitochondrial tRNAs
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz559
– volume: 36
  start-page: 6771
  year: 2016
  ident: ref_67
  article-title: Experience-Dependent Accumulation of N6-Methyladenosine in the Prefrontal Cortex Is Associated with Memory Processes in Mice
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.4053-15.2016
– volume: 186
  start-page: 27
  year: 2009
  ident: ref_39
  article-title: The nucleolar RNA methyltransferase Misu (NSun2) is required for mitotic spindle stability
  publication-title: J. Cell Biol.
  doi: 10.1083/jcb.200810180
– volume: 23
  start-page: 98
  year: 2016
  ident: ref_8
  article-title: N6-methyladenosine–encoded epitranscriptomics
  publication-title: Nat. Struct Mol. Biol
  doi: 10.1038/nsmb.3162
– volume: 57
  start-page: 393
  year: 2015
  ident: ref_79
  article-title: A Novel Single-Nucleotide Deletion (c.1020delA) in NSUN2 Causes Intellectual Disability in an Emirati Child
  publication-title: J. Mol. Neurosci.
  doi: 10.1007/s12031-015-0592-8
– volume: 17
  start-page: 2721
  year: 1999
  ident: ref_106
  article-title: Prognostic value of nucleolar protein p120 in patients with resected lung adenocarcinoma
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.1999.17.9.2721
– volume: 19
  start-page: 69
  year: 2018
  ident: ref_64
  article-title: Ythdf2-mediated m(6)A mRNA clearance modulates neural development in mice
  publication-title: Genome Biol.
  doi: 10.1186/s13059-018-1436-y
– ident: ref_113
– ident: ref_128
  doi: 10.3390/biom10040614
– volume: 14
  start-page: 60
  year: 2020
  ident: ref_133
  article-title: Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell lung cancer
  publication-title: Front. Med.
  doi: 10.1007/s11684-019-0694-8
– ident: ref_18
  doi: 10.1371/journal.pgen.1003602
– volume: 302
  start-page: 1212
  year: 2003
  ident: ref_21
  article-title: CLIP identifies Nova-regulated RNA networks in the brain
  publication-title: Science
  doi: 10.1126/science.1090095
– volume: 7
  start-page: 1143
  year: 2015
  ident: ref_56
  article-title: NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation
  publication-title: Aging (Albany NY)
  doi: 10.18632/aging.100860
– volume: 16
  start-page: 971
  year: 2006
  ident: ref_92
  article-title: The RNA methyltransferase Misu (NSun2) mediates Myc-induced proliferation and is upregulated in tumors
  publication-title: Curr. Biol.
  doi: 10.1016/j.cub.2006.04.027
– volume: 8
  start-page: 1536
  year: 2010
  ident: ref_131
  article-title: Expression of noncoding vault RNA in human malignant cells and its importance in mitoxantrone resistance
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-10-0242
– ident: ref_17
  doi: 10.3791/61231
– volume: 430
  start-page: 57
  year: 2018
  ident: ref_35
  article-title: Novel long noncoding RNA NMR promotes tumor progression via NSUN2 and BPTF in esophageal squamous cell carcinoma
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2018.05.013
– volume: 118
  start-page: 944
  year: 2016
  ident: ref_89
  article-title: NSun2 Deficiency Protects Endothelium From Inflammation via mRNA Methylation of ICAM-1
  publication-title: Circ. Res.
  doi: 10.1161/CIRCRESAHA.115.307674
– ident: ref_32
  doi: 10.3390/genes10020102
– ident: ref_126
  doi: 10.3390/pharmaceutics11070300
– volume: 34
  start-page: 3630
  year: 2014
  ident: ref_48
  article-title: Methylation by NSun2 represses the levels and function of microRNA 125b
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00243-14
– volume: 27
  start-page: 606
  year: 2017
  ident: ref_36
  article-title: 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m(5)C reader
  publication-title: Cell Res.
  doi: 10.1038/cr.2017.55
– volume: 7
  start-page: 797
  year: 2019
  ident: ref_86
  article-title: Increased m6A methylation level is associated with the progression of human abdominal aortic aneurysm
  publication-title: Ann. Transl. Med.
  doi: 10.21037/atm.2019.12.65
– volume: 2
  start-page: 1653
  year: 1975
  ident: ref_12
  article-title: The methylation state of poly A-containing messenger RNA from cultured hamster cells
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/2.10.1653
– volume: 128
  start-page: 621
  year: 2002
  ident: ref_136
  article-title: Increased nuclear localization of transcription factor YB-1 in acquired cisplatin-resistant ovarian cancer
  publication-title: J. Cancer Res. Clin. Oncol.
  doi: 10.1007/s00432-002-0386-6
– volume: 6
  start-page: 7030
  year: 2015
  ident: ref_127
  article-title: Expression of the vault RNA protects cells from undergoing apoptosis
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8030
– volume: 46
  start-page: D303
  year: 2018
  ident: ref_3
  article-title: MODOMICS: A database of RNA modification pathways. 2017 update
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkx1030
– volume: 12
  start-page: 1121
  year: 2001
  ident: ref_105
  article-title: Expression of nucleolar protein p120 predicts poor prognosis in patients with stage I lung adenocarcinoma
  publication-title: Ann. Oncol.
  doi: 10.1023/A:1011617707999
– volume: 11
  start-page: 476
  year: 2020
  ident: ref_137
  article-title: YBX1 mediates autophagy by targeting p110β and decreasing the sensitivity to cisplatin in NSCLC
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-020-2555-4
– volume: 19
  start-page: 900
  year: 2012
  ident: ref_52
  article-title: RNA cytosine methylation by Dnmt2 and NSun2 promotes tRNA stability and protein synthesis
  publication-title: Nat. Struct. Mol. Biol.
  doi: 10.1038/nsmb.2357
– volume: 19
  start-page: 882
  year: 2020
  ident: ref_139
  article-title: Targeting Phosphorylation of Y-Box-Binding Protein YBX1 by TAS0612 and Everolimus in Overcoming Antiestrogen Resistance
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-19-0690
– volume: 4
  start-page: 38
  year: 2017
  ident: ref_99
  article-title: Circular RNAs: Biogenesis, Function and Role in Human Diseases
  publication-title: Front. Mol. Biosci.
  doi: 10.3389/fmolb.2017.00038
– volume: 35
  start-page: 4043
  year: 2015
  ident: ref_55
  article-title: NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.00742-15
– volume: 10
  start-page: 289
  year: 2020
  ident: ref_122
  article-title: Sphingosine Kinase 1 in Breast Cancer-A New Molecular Marker and a Therapy Target
  publication-title: Front. Oncol.
  doi: 10.3389/fonc.2020.00289
– volume: 7
  start-page: 19099
  year: 2016
  ident: ref_50
  article-title: RNA methyltransferase NSUN2 promotes stress-induced HUVEC senescence
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8087
– volume: 156
  start-page: 121
  year: 2019
  ident: ref_16
  article-title: BisAMP: A web-based pipeline for targeted RNA cytosine-5 methylation analysis
  publication-title: Methods
  doi: 10.1016/j.ymeth.2018.10.013
– volume: 8
  start-page: 275
  year: 1992
  ident: ref_31
  article-title: The rapid generation of mutation data matrices from protein sequences
  publication-title: Comput. Appl. Biosci.
– ident: ref_146
  doi: 10.3390/molecules24244492
– volume: 24
  start-page: 1590
  year: 2010
  ident: ref_73
  article-title: RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
  publication-title: Genes Dev.
  doi: 10.1101/gad.586710
– volume: 13
  start-page: 319
  year: 2013
  ident: ref_43
  article-title: Expression of NOL1/NOP2/sun domain (Nsun) RNA methyltransferase family genes in early mouse embryogenesis
  publication-title: Gene Expr. Patterns
  doi: 10.1016/j.gep.2013.06.003
– volume: 33
  start-page: 2020
  year: 2014
  ident: ref_41
  article-title: Aberrant methylation of tRNAs links cellular stress to neuro-developmental disorders
  publication-title: EMBO J.
  doi: 10.15252/embj.201489282
– volume: 8
  start-page: 20751
  year: 2017
  ident: ref_97
  article-title: Overexpression of NSUN2 by DNA hypomethylation is associated with metastatic progression in human breast cancer
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.10612
– volume: 36
  start-page: 246
  year: 2018
  ident: ref_118
  article-title: High tRNA Transferase NSUN2 Gene Expression is Associated with Poor Prognosis in Head and Neck Squamous Carcinoma
  publication-title: Cancer Invest.
  doi: 10.1080/07357907.2018.1466896
– volume: 19
  start-page: 649
  year: 2017
  ident: ref_94
  article-title: UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses
  publication-title: Neoplasia
  doi: 10.1016/j.neo.2017.05.002
– volume: 149
  start-page: 1635
  year: 2012
  ident: ref_10
  article-title: Comprehensive analysis of mRNA methylation reveals enrichment in 3′ UTRs and near stop codons
  publication-title: Cell
  doi: 10.1016/j.cell.2012.05.003
– volume: 99
  start-page: 163
  year: 2020
  ident: ref_76
  article-title: Mitochondria at the interface between neurodegeneration and neuroinflammation
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2019.05.028
– volume: 51
  start-page: 1092
  year: 2019
  ident: ref_78
  article-title: Recessive gene disruptions in autism spectrum disorder
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0433-8
– volume: 36
  start-page: 44
  year: 2020
  ident: ref_11
  article-title: The Biogenesis and Precise Control of RNA m(6)A Methylation
  publication-title: Trends Genet.
  doi: 10.1016/j.tig.2019.10.011
– ident: ref_26
  doi: 10.1186/s12915-020-00769-5
– volume: 19
  start-page: 2999
  year: 2019
  ident: ref_49
  article-title: Expression profiles of long noncoding RNAs associated with the NSUN2 gene in HepG2 cells
  publication-title: Mol. Med. Rep.
– volume: 17
  start-page: 474
  year: 2020
  ident: ref_98
  article-title: Pan-cancer analysis of RNA methyltransferases identifies FTSJ3 as a potential regulator of breast cancer progression
  publication-title: RNA Biol.
  doi: 10.1080/15476286.2019.1708549
– volume: 10
  start-page: 4695
  year: 2019
  ident: ref_100
  article-title: N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12651-2
– volume: 86
  start-page: 134
  year: 2014
  ident: ref_80
  article-title: Whole exome sequencing unravels disease-causing genes in consanguineous families in Qatar
  publication-title: Clin. Genet.
  doi: 10.1111/cge.12280
– volume: 38
  start-page: 2551
  year: 2019
  ident: ref_114
  article-title: LCE: An open web portal to explore gene expression and clinical associations in lung cancer
  publication-title: Oncogene
  doi: 10.1038/s41388-018-0588-2
– volume: 71
  start-page: 3971
  year: 1974
  ident: ref_7
  article-title: Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cells
  publication-title: Proc. Natl. Acad. Sci USA
  doi: 10.1073/pnas.71.10.3971
– volume: 90
  start-page: 847
  year: 2012
  ident: ref_72
  article-title: Mutations in NSUN2 cause autosomal-recessive intellectual disability
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2012.03.021
– volume: 56
  start-page: 1896
  year: 1996
  ident: ref_101
  article-title: Human colorectal carcinomas express high levels of high mobility group HMGI(Y) proteins
  publication-title: Cancer Res.
– volume: 355
  start-page: 130
  year: 2014
  ident: ref_103
  article-title: HMGA2 induces transcription factor Slug expression to promote epithelial-to-mesenchymal transition and contributes to colon cancer progression
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2014.09.007
– volume: 11
  start-page: 3604
  year: 2005
  ident: ref_141
  article-title: Approval summary: Azacitidine for treatment of myelodysplastic syndrome subtypes
  publication-title: Clin. Cancer Res.
  doi: 10.1158/1078-0432.CCR-04-2135
– volume: 35
  start-page: 1547
  year: 2018
  ident: ref_29
  article-title: MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms
  publication-title: Mol. Biol. Evol.
  doi: 10.1093/molbev/msy096
– volume: 563
  start-page: 249
  year: 2018
  ident: ref_65
  article-title: m(6)A facilitates hippocampus-dependent learning and memory through YTHDF1
  publication-title: Nature
  doi: 10.1038/s41586-018-0666-1
– ident: ref_109
  doi: 10.1371/journal.pone.0015145
– volume: 99
  start-page: 283
  year: 2018
  ident: ref_62
  article-title: Mettl14 Is Essential for Epitranscriptomic Regulation of Striatal Function and Learning
  publication-title: Neuron
  doi: 10.1016/j.neuron.2018.06.007
– volume: 235
  start-page: 1488
  year: 1960
  ident: ref_1
  article-title: Pseudouridine, a carbon-carbon linked ribonucleoside in ribonucleic acids: Isolation, structure, and chemical characteristics
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)69432-3
– volume: 21
  start-page: 430
  year: 2012
  ident: ref_143
  article-title: Transient low doses of DNA-demethylating agents exert durable antitumor effects on hematological and epithelial tumor cells
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.12.029
– volume: 31
  start-page: 660
  year: 2012
  ident: ref_93
  article-title: Frequent increased gene copy number and high protein expression of tRNA (cytosine-5-)-methyltransferase (NSUN2) in human cancers
  publication-title: DNA Cell Biol.
  doi: 10.1089/dna.2011.1446
– volume: 520
  start-page: 60
  year: 2019
  ident: ref_37
  article-title: Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1016/j.bbrc.2019.09.098
– volume: 49
  start-page: 380
  year: 2012
  ident: ref_77
  article-title: Whole exome sequencing identifies a splicing mutation in NSUN2 as a cause of a Dubowitz-like syndrome
  publication-title: J. Med. Genet.
  doi: 10.1136/jmedgenet-2011-100686
– volume: 5
  start-page: 891
  year: 2006
  ident: ref_142
  article-title: Decitabine
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2180
– volume: 195
  start-page: 85
  year: 2019
  ident: ref_124
  article-title: The sphingosine kinase-1/sphingosine-1-phosphate axis in cancer: Potential target for anticancer therapy
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2018.10.011
– volume: 20
  start-page: 303
  year: 2020
  ident: ref_91
  article-title: Role of RNA modifications in cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-020-0253-2
– volume: 4
  start-page: 255
  year: 2013
  ident: ref_23
  article-title: NSun2-mediated cytosine-5 methylation of vault noncoding RNA determines its processing into regulatory small RNAs
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2013.06.029
– volume: 18
  start-page: 245
  year: 2020
  ident: ref_19
  article-title: Overview of distinct 5-methylcytosine profiles of messenger RNA in human hepatocellular carcinoma and paired adjacent non-tumor tissues
  publication-title: J. Transl. Med.
  doi: 10.1186/s12967-020-02417-6
– volume: 90
  start-page: 856
  year: 2012
  ident: ref_81
  article-title: Mutation in NSUN2, which encodes an RNA methyltransferase, causes autosomal-recessive intellectual disability
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2012.03.023
SSID ssj0000816105
Score 2.5234845
SecondaryResourceType review_article
Snippet 5-methylcytosine is often associated as an epigenetic modifier in DNA. However, it is also found increasingly in a plethora of RNA species, predominantly...
SourceID doaj
pubmedcentral
proquest
gale
pubmed
crossref
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
StartPage 1758
SubjectTerms 5-methylcytosine
5-Methylcytosine - metabolism
Animals
Breast Neoplasms - enzymology
cancer
Carcinogenesis
Cell adhesion & migration
Cell cycle
Colorectal Neoplasms - enzymology
Deoxyribonucleic acid
DNA
DNA methylation
DNA methyltransferase
epi-transcriptome
Female
Gene expression
Genetic aspects
Health aspects
Humans
Lung Neoplasms - enzymology
Mammalian cells
Methylation
Methyltransferases
Methyltransferases - genetics
Methyltransferases - metabolism
Mice
miRNA
Mitochondria
mRNA
Neurological disorders
Non-small cell lung carcinoma
Phylogeny
Physiological aspects
Proteins
Review
RNA
RNA modification
RNA, Messenger - metabolism
Roles
Small cell lung carcinoma
Transfer RNA
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Na-MwEBWlUNjLsu1-uU2LCt3TYipLsiUd09LSFhJKdwO9CUuW2EJxSuIc-u87YzvBYVl62UMgWIqR52k8b5zxG0LONI8esmSfApsOkKBon-qIgJSauUz5GEt8G3kyLW5m8u4xfxy0-sKasE4euDPcucu0jlVeONiLEv_FKnNRGR8rD9vRF616KcS8QTLV3oM1MBmWd5XuAvL6c3wOvjRwXGF390EMaqX6_74hDyLSdrXkIPxcfyIfe95Ix91698lOqA_IXtdJ8vUzGQPc9GE6ppMAln9uWjoaFhCi6PTXbMppWVf0tlnS-3mD9UFwqgeUcqJPNb1E4BdfyOz66vflTdp3R0h9zoomdQ7CinDcQ3wxDkVt8KXaoLlxQkoTAligVFGKkMHaJRjfR6B74NSVMrpi4ivZred1-E5oqbgIChIX5oUsWXTa5MxnlVLwtWAmIT_X9rK-lw7HDhbPFlIItK4dWjchPzazXzrJjH_Mu0DTb-ag0HV7AOC3Pfz2PfgTMkLgLLojLMmDc3g7LiQ2Gyza4TWgtnfOpQVWgpo-8EnI6WYYf4kFZ3WYr7o53EhTqIR86_DfLFRwBTw7g5OrrZ2xdSXbI_XTn1a6W0kkePzwf1z6EfnAMflnKuV8RHabxSocA0Nq3EnrDG8sDAuj
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: ProQuest Central
  dbid: BENPR
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfR3LatwwULQbCr2Uvus0LSq0p2JiS7IlncomJKSFmLDtQm7CkqU0EOx01znk7ztja91dSnswGEk2oxnNSxrNEPJRseDAS3YpWNMeHBTlUhWQILXKbC5dCDXeRj6vyrOl-HZZXMYNt3UMq9zIxEFQN53DPfJDUCWYiAWeL7e_UqwahaersYTGQ7IHIlipGdk7OqkuFtMuC5aVAAtijHjn4N8f4n74WkO7xCrvW7poSNn_t2De0ky7UZNbauj0KXkS7Uc6Hwn-jDzw7XPyaKwoef-CzIHsdFHN6bkHCtz0g1nqV6CqaPV9WTFatw392q_pRddjnBD8aoEpneh1S49xAaxekuXpyY_jszRWSUhdkZV9ai2oF26ZAz2jLSa3wcu1XjFtuRDae8BALYPgPgfYBRDBBTD7gLkbqVWT8Vdk1natf0NoLRn3EhyYzHFRZ8EqXWQub6SE1zLTCfm8wZdxMYU4VrK4MeBKIHbNNnYT8mkafTumzvjHuCNE_TQGE14PDd3qykT-MTZXKjRFaWF6Ag8z64I32oXGgVRyZZGQAyScQbYEkBwwiTPzUmDRwXLo3hDURCZdmz9LKiEfpm78EgPPWt_djWOYFrqUCXk90n8ClDMJ9nYOP5c7K2NnJrs97fXPIYW3FGjosf3_g_WWPGbo3mcyZeyAzPrVnX8HNlBv38eF_hutLATJ
  priority: 102
  providerName: ProQuest
Title The RNA Methyltransferase NSUN2 and Its Potential Roles in Cancer
URI https://www.ncbi.nlm.nih.gov/pubmed/32708015
https://www.proquest.com/docview/2427348734
https://www.proquest.com/docview/2427294967
https://pubmed.ncbi.nlm.nih.gov/PMC7463552
https://doaj.org/article/b188fd56b07343858a53d9cfdc031c65
Volume 9
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3da9swED-6lsFexr7nrgsabE_Dmy3LlvQwRlpaukFMyRbom7BkeSsEZ3NcaP_73dlOiOkGewiESBHyfeh-P_t8B_BW8cohS3YhommPBEW5UFWkkEJFNpauqgp6G3mWZ-cL8fUyvdyDTbfRQYDrv1I76ie1aJYfbn7ffkaH_0SMEyn7R7rFvdYY2xD73oMDjEmSehnMBqDfnckKkU2Xz8jRpkOBrKbPgr-zwCg-dWX87x7WO9FqnEm5E5rOHsHDAVOyaW8Ej2HP10_gft9l8vYpTNEU2DyfsplHrSzbDqr6BsMXy78tcs6KumRf2jW7WLWUO4RLzanME7uq2QkZRfMMFmen30_Ow6FzQujSKGtDazHkJJY7jD3aUsEbeuHWK65tIoT2HqVRyEokPsa9C1SMqxAKosOXUqsySp7Dfr2q_UtgheSJl0hqIpeIIqqs0mnk4lJK_JpFOoD3G3kZN5QVp-4WS4P0gqRrdqUbwLvt7F99OY1_zDsm0W_nUBHs7odV88MMPmVsrFRVppnFyxP0gLNIk1K7qnR4UrksDeCIFGfIeHBLDh3HmWkmqBFh1g1vFGo2dmcQsVC9H_wE8GY7TP-kZLTar677OVwLnckAXvT632404RIxeIyLy5FljK5kPFJf_ezKektB4I8f_qeIXsEDTtw_kiHnR7DfNtf-NQKk1k7g4Pg0v5hPuhsMk84T_gAmWA2d
linkProvider Scholars Portal
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwEB6VrRBcEG8CBYxETyhqYjtxckBoW1rt0m5ULV2pNzdxHFqpStrdVKh_it_ITB7LrhDceogUxY7lzIzn4YznA_gY8cJglGxc9KYtBiiRcaOCGJJGXuYrUxQpnUaeJOFoJr-dBqcb8Ks_C0Nplb1ObBR1XhnaI99BU0KFWPD6cnXtEmoU_V3tITRasTi0tz8xZFt8Hn9F_m5zfrB_sjdyO1QB1wReWLtZhupYZNygXo4zKgZDh1FtxONMSBlbiz5QqgoprG9zI3HSpkA3CRdDruIo9wSOew82pQg9PoDN3f3keLrc1SEYC_RY2gx7gW_t0P77IsbnilDlV2xfAxHwtyFYsYTrWZorZu_gMTzq_FU2bAXsCWzY8incbxEsb5_BEMWMTZMhm1jk-GXduMF2jqaRJd9nCWdpmbNxvWDHVU15STjUlEpIsYuS7ZHAzZ_D7E7o9wIGZVXaV8BSxYVVGDB5RsjUK7IoDjzj50rhbejFDnzq6aVNV7KckDMuNYYuRF29Sl0Htpe9r9pSHf_ot0ukX_ahAtvNg2r-Q3frVWd-FBV5EGb4eZJ-nqaByGNT5Aa1oAkDB7aIcZrUAE7J4KI0ehhKAjkMm-aeobpTCgv9R4Qd-LBspjcp0a201U3bh8cyDpUDL1v-LycquEL_3sfB1ZpkrH3Jekt5cd6UDFeSHEv--v_Teg8PRieTI300Tg7fwENOWwuecjnfgkE9v7Fv0f-qs3ed0DM4u-t19hv6FT_8
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtR1db9Mw8DQ6gXhBfBPYwEjsCUVNnA_HDwh1H9XKWFQVKu3NJI4Nk6ZktJnQ_hq_jrskzVoheNtDpCh2LPu-zz7fAbxLuNXoJWsXrWmDDkqi3cQSQrLEy32hrc3oNvJpGh_Pw09n0dkW_F7dhaGwypVMbAR1UWnaIx-iKqFELPgMbRcWMT0cf7z86VIFKTppXZXTaEnkxFz_Qvdt-WFyiLje43x89PXg2O0qDLg68uLazXMUzUHONcpomVNiGLqYahIu8yAMpTFoD2XChoHxTaFDXIC2aDIhYxRCJoUX4Lh3YFuQVzSA7f2jdDrrd3iopAVaL220fYB_DWkvfinxu6AK82t6sCkX8LdSWNOKmxGbaypw_BAedLYrG7XE9gi2TPkY7rbVLK-fwAhJjs3SETs1iP2LujGJzQLVJEu_zFPOsrJgk3rJplVNMUo41IzSSbHzkh0Q8S2ewvxW4PcMBmVVmhfAMsEDI9B58nQQZp7NExl52i-EwNfYkw68X8FL6S59OVXRuFDoxhB01Tp0Hdjre1-2aTv-0W-fQN_3oWTbzYdq8V11vKtyP0lsEcU5Li-kg9QsCgqpbaFRIuo4cmCHEKdIJOCUNDKoVqM4pIKHcdO8QqjqBMRS3ZCzA2_7ZvqTgt5KU121fbgMZSwceN7iv59owAXa-j4OLjYoY2Mlmy3l-Y8mfbgIycjkL_8_rTdwD_lLfZ6kJ6_gPqddBk-4nO_AoF5cmV00xer8dUfzDL7dNpv9AflqRDE
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+RNA+Methyltransferase+NSUN2+and+Its+Potential+Roles+in+Cancer&rft.jtitle=Cells+%28Basel%2C+Switzerland%29&rft.au=Chellamuthu%2C+Anitha&rft.au=Gray%2C+Steven+G.&rft.date=2020-07-22&rft.issn=2073-4409&rft.eissn=2073-4409&rft.volume=9&rft.issue=8&rft.spage=1758&rft_id=info:doi/10.3390%2Fcells9081758&rft.externalDBID=n%2Fa&rft.externalDocID=10_3390_cells9081758
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2073-4409&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2073-4409&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2073-4409&client=summon