A Critical Analysis of the Tumor Volume Threshold for Clinically Insignificant Prostate Cancer Using a Data Set of a Randomized Screening Trial

• Published in: The Journal of urology Vol. 185; no. 1; pp. 121 - 125
• Main Authors: Wolters, Tineke, Roobol, Monique J, van Leeuwen, Pim J, van den Bergh, Roderick C.N, Hoedemaeker, Robert F, van Leenders, Geert J.L.H, Schröder, Fritz H, van der Kwast, Theodorus H
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 2011; Elsevier
• Subjects: Aged; Biological and medical sciences; early detection of cancer; Gynecology. Andrology. Obstetrics; Humans; Male; Male genital diseases; Medical sciences; Middle Aged; Nephrology. Urinary tract diseases; Organ Size; prostatic neoplasms; Prostatic Neoplasms - pathology; Randomized Controlled Trials as Topic; tumor burden; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urology; TV; tumor volume; clinical tumor; prostate specific antigen; ERSPC; cT; European Randomized Study of Screening for Prostate Cancer; prostate cancer; PC; radical prostatectomy; early detection of cancer; prostatic neoplasms; tumor burden; RP; PSA; Prostate tumor; Nephrology; Urinary system disease; Prostate disease; Early stage; Malignant tumor; Medical screening; Urology; Randomization; Volume; Clinical trial; Male genital diseases; Prostate cancer; Cancer; Threshold

Purpose The identification of clinically insignificant prostate cancer could help avoid overtreatment. Current criteria for insignificant prostate cancer use a tumor volume threshold of less than 0.5 ml for the index tumor. In this study we reassess this tumor volume threshold for clinically insigni...