Nanocrystal Formulation to Enhance Oral Absorption of Silybin: Preparation, In Vitro Evaluations, and Pharmacokinetic Evaluations in Rats and Healthy Human Subjects - Seo, SeungRee; Kim, Gwan-Young; Kim, Min-Hwan; Lee, Kyung Won; Kim, Min-Jae; Chaudhary, Mansingh; Bikram, Khadka; Kim, Taeheon; Choi, Seungmok; Yang, Heejin; Park, Joo Won; Kim, Dae-Duk; et al. (Pharmaceutics, 2024)
Keywords: Drug delivery systems; Drug dosages; Homogenization; human pharmacokinetic; long-term stability; Methods; milk thistle; Morphology; nanocrystal; Nanocrystals; Nanoparticles; oral bioavailability; Particle size; Pharmaceuticals; Pharmacokinetics; Raw materials; Reproducibility; Scanning electron microscopy; Sedimentation & deposition; silybin; Solvents; Toxicity; South Korea; United States--US; Japan; Germany; India; nanocrystal; long-term stability; oral bioavailability; milk thistle; silybin; human pharmacokinetic