Single-dose VSV-based vaccine protects cynomolgus macaques from disease after Taï Forest virus infection

• Published in: Emerging microbes & infections Vol. 12; no. 2; p. 2239950
• Main Authors: Fletcher, Paige, O'Donnell, Kyle L, Doratt, Brianna M, Malherbe, Delphine C, Clancy, Chad S, Rhoderick, Joseph F, Feldmann, Friederike, Hanley, Patrick W, Ksiazek, Thomas G, Geisbert, Thomas W, Messaoudi, Ilhem, Marzi, Andrea
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Ltd 01.12.2023; Taylor & Francis; Taylor & Francis Group
• Subjects: Antigens; Ebola; Filovirus; live-attenuated vaccine; nonhuman primate; Taï forest ebolavirus; transcriptomics; Vaccines; vesicular stomatitis virus; transcriptomics; Taï forest ebolavirus; nonhuman primate; Filovirus; live-attenuated vaccine; vesicular stomatitis virus

Taï Forest virus (TAFV) is a lesser-known ebolavirus that causes lethal infections in chimpanzees and is responsible for a single human case. Limited research has been done on this human pathogen; however, with the recent emergence of filoviruses in West Africa, further investigation and countermeas...