IL-5Rα marks nasal polyp IgG4- and IgE-expressing cells in aspirin-exacerbated respiratory disease

• Published in: Journal of allergy and clinical immunology Vol. 145; no. 6; pp. 1574 - 1584
• Main Authors: Buchheit, Kathleen M., Dwyer, Daniel F., Ordovas-Montanes, Jose, Katz, Howard R., Lewis, Erin, Vukovic, Marko, Lai, Juying, Bankova, Lora G., Bhattacharyya, Neil, Shalek, Alex K., Barrett, Nora A., Boyce, Joshua A., Laidlaw, Tanya M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2020
• Subjects: Adult; Aged; Antibodies - metabolism; Aspirin - adverse effects; Aspirin-exacerbated respiratory disease; chronic rhinosinusitis; Female; Humans; IgE; IgG4; IL-5Rα; Immunoglobulin E - metabolism; Immunoglobulin G - metabolism; interleukin-5; Interleukin-5 - metabolism; Interleukin-5 Receptor alpha Subunit - metabolism; Male; Middle Aged; nasal polyposis; Nasal Polyps - chemically induced; Nasal Polyps - metabolism; plasma cell; Plasma Cells - drug effects; Plasma Cells - metabolism; Sequence Analysis, RNA - methods; Sinusitis - chemically induced; Sinusitis - metabolism; Young Adult; UMAP; CRS; Aspirin-exacerbated respiratory disease; IgE; AERD; IgG4; CRSwNP; nasal polyposis; CRSsNP; interleukin-5; scRNA-seq; SPRI; PC; F(ab')2; chronic rhinosinusitis; qPCR; IL-5Rα; plasma cell
• ISSN: 0091-6749; 1097-6825; 1097-6825
• DOI: 10.1016/j.jaci.2020.02.035

The cause of severe nasal polyposis in aspirin-exacerbated respiratory disease (AERD) is unknown. Elevated antibody levels have been associated with disease severity in nasal polyps, but upstream drivers of local antibody production in nasal polyps are undetermined. We sought to identify upstream dr...