Effects and mechanism of Aβ1−42 on EV-A71 replication

• Published in: Virology journal Vol. 19; no. 1; p. 151
• Main Authors: Zhong, Ming, Wang, Huiqiang, Yan, Haiyan, Wu, Shuo, Wang, Kun, Yang, Lu, Cui, Boming, Wu, Mengyuan, Li, Yuhuan
• Format: Journal Article
• Language: English
• Published: London BioMed Central 20.09.2022; BMC
• Subjects: Agglutination; Alzheimer disease; Alzheimer's disease; Antibodies; brain; Capsid protein; Capsid protein VP1; class; coat proteins; Cold; Enterovirus A; Enterovirus A 71; Enteroviruses; Enzyme-linked immunosorbent assay; Experiments; fluorescent antibody technique; Herpes simplex; Human alphaherpesvirus 1; humans; Immunofluorescence; Infections; Influenza A; Influenza A virus; Life cycles; Membranes; Neurodegenerative diseases; Neurological diseases; Peptides; Proteins; Replication; Rhabdomyosarcoma; RNA; Scavenger receptor class B member 2; Scavenger receptors; Senile plaques; viral nonstructural proteins; virus replication; Viruses; VP1 protein; Western blotting; β-Amyloid; β-Amyloid protein; United States > US; China; California

Background β-Amyloid (Aβ) protein is a pivotal pathogenetic factor in Alzheimer’s disease (AD). However, increasing evidence suggests that the brain has to continuously produce excessive Aβ to efficaciously prevent pathogenic micro-organism infections, which induces and accelerates the disease proce...