Effects of Coronavirus Persistence on the Genome Structure and Subsequent Gene Expression, Pathogenicity and Adaptation Capability

• Published in: Cells (Basel, Switzerland) Vol. 9; no. 10; p. 2322
• Main Authors: Lin, Ching-Hung, Yang, Cheng-Yao, Wang, Meilin, Ou, Shan-Chia, Lo, Chen-Yu, Tsai, Tsung-Lin, Wu, Hung-Yi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19.10.2020; MDPI
• Subjects: Adaptation; Animals; Betacoronavirus - genetics; Cattle; Cell Line; Computational Biology; coronavirus; Coronavirus Infections - pathology; Coronavirus Infections - virology; Coronavirus, Bovine - genetics; Coronaviruses; Disease control; DNA polymerase; Gene expression; Gene Expression Regulation, Viral - genetics; Genetic aspects; genome structure; Genome, Viral - genetics; Genomes; Health aspects; Humans; Infections; Medical research; Microbiological research; Mutation; Pathogenicity; persistence; Persistent infection; Physiological adaptation; Physiological aspects; Proteins; Regulatory sequences; Regulatory Sequences, Ribonucleic Acid - genetics; RNA, Messenger - genetics; RNA, Viral - genetics; SARS-CoV-2; Severe acute respiratory syndrome coronavirus 2; Transcription; Transcription, Genetic - genetics; virus fitness; Viruses; Taiwan; United States > US; pathogenicity; coronavirus; persistence; virus fitness; genome structure; gene expression

Coronaviruses are able to establish persistence. However, how coronaviruses react to persistence and whether the selected viruses have altered their characteristics remain unclear. In this study, we found that the persistent infection of bovine coronavirus (BCoV), which is in the same genus as SARS-...