Apolipoprotein(a) production and clearance are associated with plasma IL-6 and IL-18 levels, dependent on ethnicity

• Published in: Atherosclerosis Vol. 391; p. 117474
• Main Authors: Groenen, Anouk G., Matveyenko, Anastasiya, Matienzo, Nelsa, Halmos, Benedek, Zhang, Hanrui, Westerterp, Marit, Reyes-Soffer, Gissette
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.04.2024
• Subjects: APO(a) isoform size; APO(a) kinetics; Apolipoproteins A; Apoprotein(a); ASCVD; Atherosclerosis; Ethnicity; Humans; Inflammation; Interleukin-18; Interleukin-6; Kinetics; Lipoprotein(a); Protein Isoforms - metabolism; APO(a) isoform size; Lipoprotein(a); Inflammation; ASCVD; APO(a) kinetics

High plasma lipoprotein (a) [Lp(a)] levels are associated with increased atherosclerotic cardiovascular disease (ASCVD), in part attributed to elevated inflammation. High plasma Lp(a) levels inversely correlate with apolipoprotein (a) [(APO(a)] isoform size. APO(a) isoform size is negatively associa...