Inducible expression of basic transcription element–binding protein 2 in proliferating smooth muscle cells at the vascular anastomotic stricture

• Published in: The Journal of thoracic and cardiovascular surgery Vol. 119; no. 5; pp. 983 - 989
• Main Authors: Ogata, Toshiro, Kurabayashi, Masahiko, Hoshino, Yo-ichi, Sekiguchi, Ken-ichi, Ishikawa, Susumu, Morishita, Yasuo, Nagai, Ryozo
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.05.2000; AATS/WTSA
• Subjects: Anastomosis, Surgical; Animals; Aorta, Abdominal - metabolism; Aorta, Abdominal - pathology; Aorta, Abdominal - surgery; Biomarkers; Blotting, Southern; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinases - biosynthesis; Cyclin-Dependent Kinases - genetics; Gene Expression; Immunoenzyme Techniques; Kruppel-Like Transcription Factors; Male; Muscle, Smooth, Vascular - metabolism; Muscle, Smooth, Vascular - pathology; Muscle, Smooth, Vascular - surgery; Proto-Oncogene Proteins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - biosynthesis; Sp1 Transcription Factor - biosynthesis; Sp1 Transcription Factor - genetics; Trans-Activators - biosynthesis; Trans-Activators - genetics; Wound Healing - physiology

Objective: The proliferation of vascular smooth muscle cells surrounding a suture line is an important factor in the development of anastomotic stricture that is frequently seen after coronary artery bypass grafting. The aim of this study was to investigate the time course of intimal thickening and...