Serum Biomarker Panels for the Detection of Pancreatic Cancer

• Published in: Clinical cancer research Vol. 17; no. 4; pp. 805 - 816
• Main Authors: Brand, Randall E., Nolen, Brian M., Zeh, Herbert J., Allen, Peter J., Eloubeidi, Mohamad A., Goldberg, Michael, Elton, Eric, Arnoletti, Juan P., Christein, John D., Vickers, Selwyn M., Langmead, Christopher J., Landsittel, Douglas P., Whitcomb, David C., Grizzle, William E., Lokshin, Anna E.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.02.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic agents; Biological and medical sciences; Biomarkers, Tumor - blood; Blood Proteins - metabolism; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - metabolism; Case-Control Studies; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Middle Aged; Molecular Diagnostic Techniques - methods; Molecular Diagnostic Techniques - statistics & numerical data; Multivariate Analysis; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - metabolism; Pharmacology. Drug treatments; ROC Curve; Sensitivity and Specificity; Tumors; Young Adult; Biological fluid; Pancreas cancer; Biological marker; Digestive diseases; Serum; Malignant tumor; Diagnosis; Detection; Cancer; Pancreatic disease

Purpose: Serum–biomarker based screening for pancreatic cancer could greatly improve survival in appropriately targeted high-risk populations. Experimental Design: Eighty-three circulating proteins were analyzed in sera of patients diagnosed with pancreatic ductal adenocarcinoma (PDAC, n = 333), ben...