Impaired immunogenicity to COVID-19 vaccines in autoimmune systemic diseases. High prevalence of non-response in different patients’ subgroups

• Published in: Journal of autoimmunity Vol. 125; p. 102744
• Main Authors: Ferri, Clodoveo, Ursini, Francesco, Gragnani, Laura, Raimondo, Vincenzo, Giuggioli, Dilia, Foti, Rosario, Caminiti, Maurizio, Olivo, Domenico, Cuomo, Giovanna, Visentini, Marcella, Cacciapaglia, Fabio, Pellegrini, Roberta, Pigatto, Erika, Urraro, Teresa, Naclerio, Caterina, Tavoni, Antonio, Puccetti, Lorenzo, Varcasia, Giuseppe, Cavazzana, Ilaria, L'Andolina, Massimo, Ruscitti, Piero, Vadacca, Marta, Gigliotti, Pietro, La Gualana, Francesca, Cozzi, Franco, Spinella, Amelia, Visalli, Elisa, Dal Bosco, Ylenia, Amato, Giorgio, Masini, Francesco, Pagano Mariano, Giuseppa, Brittelli, Raffaele, Aiello, Vincenzo, Caminiti, Rodolfo, Scorpiniti, Daniela, Rechichi, Giovanni, Ferrari, Tommaso, Monti, Monica, Elia, Giusy, Franceschini, Franco, Meliconi, Riccardo, Casato, Milvia, Iannone, Florenzo, Giacomelli, Roberto, Fallahi, Poupak, Santini, Stefano Angelo, Zignego, Anna Linda, Antonelli, Alessandro
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2021
• Subjects: 2019-nCoV Vaccine mRNA-1273 - immunology; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Autoimmune Diseases - blood; Autoimmune Diseases - immunology; Autoimmune systemic diseases; BNT162 Vaccine - immunology; COVID-19 - prevention & control; COVID-19 vaccine; Cryoglobulinemic vasculitis; Female; Humans; Italy; Lupus Erythematosus, Systemic - immunology; Male; Middle Aged; Neutralizing antibodies; Prospective Studies; Rheumatoid arthritis; SARS-CoV-2 - immunology; Scleroderma, Systemic - immunology; Systemic lupus; Systemic sclerosis; Systemic vasculitis; Systemic Vasculitis - immunology; Vaccination; Vaccine Potency; Italy; World Health Organization; Neutralizing antibodies; Systemic lupus; Autoimmune systemic diseases; Neutralizing antibody; Rheumatoid factor; Anti-citrullinated protein antibodies; Systemic lupus erythematosus; Adverse events; Systemic sclerosis; Rheumatoid arthritis; Binding Antibody Units; COVID-19 vaccine; Systemic vasculitis; Cryoglobulinemic vasculitis

Autoimmune systemic diseases (ASD) may show impaired immunogenicity to COVID-19 vaccines. Our prospective observational multicenter study aimed to evaluate the seroconversion after the vaccination cycle and at 6-12-month follow-up, as well the safety and efficacy of vaccines in preventing COVID-19....