Inflammation and arterial stiffness in humans

Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summar...

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Published inAtherosclerosis Vol. 237; no. 2; pp. 381 - 390
Main Authors Jain, Snigdha, Khera, Rohan, Corrales–Medina, Vicente F., Townsend, Raymond R., Chirinos, Julio A.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 01.12.2014
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Abstract Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections. •In the general population, inflammatory biomarkers are associated with arterial stiffness.•Patients with primary inflammatory disorders have increased large artery stiffness.•Experimental induction of inflammation increases arterial stiffness suggesting causative role.•Anti-inflammatory therapy has largely been shown to reduce arterial stiffness.
AbstractList Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections. •In the general population, inflammatory biomarkers are associated with arterial stiffness.•Patients with primary inflammatory disorders have increased large artery stiffness.•Experimental induction of inflammation increases arterial stiffness suggesting causative role.•Anti-inflammatory therapy has largely been shown to reduce arterial stiffness.
Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections.
Abstract Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections.
Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections.Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are established factors contributing to arterial stiffness, the role of inflammation in stiffening of the arteries is less well understood. We summarize existing literature regarding inflammation and arterial stiffness, including a discussion of the potential mechanisms by which inflammation may lead to arterial stiffening and studies assessing: (1) The association between subclinical inflammation and arterial stiffness in the general population; (2) The presence of increased arterial stiffness in primary inflammatory diseases; (3) The effect of anti-inflammatory therapy on arterial stiffness in primary inflammatory disease including the effect of statins; (4) Experimental evidence of immunization-induced arterial stiffening in normal adults. We discuss potential opportunities to assess the impact of anti-inflammatory interventions on arterial stiffness in subjects without primary inflammatory conditions. We also review the effect of inflammation on wave reflections.
Author Khera, Rohan
Townsend, Raymond R.
Jain, Snigdha
Corrales–Medina, Vicente F.
Chirinos, Julio A.
Author_xml – sequence: 1
  givenname: Snigdha
  surname: Jain
  fullname: Jain, Snigdha
  organization: University of Iowa Hospitals and Clinics, Iowa City, IA, USA
– sequence: 2
  givenname: Rohan
  surname: Khera
  fullname: Khera, Rohan
  organization: University of Iowa Hospitals and Clinics, Iowa City, IA, USA
– sequence: 3
  givenname: Vicente F.
  surname: Corrales–Medina
  fullname: Corrales–Medina, Vicente F.
  organization: University of Ottawa and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada
– sequence: 4
  givenname: Raymond R.
  surname: Townsend
  fullname: Townsend, Raymond R.
  organization: University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19060, USA
– sequence: 5
  givenname: Julio A.
  surname: Chirinos
  fullname: Chirinos, Julio A.
  email: julio.chirinos@uphs.upenn.edu
  organization: University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19060, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25463062$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords Pulse wave velocity
Inflammation
Arterial stiffness
Cardiovascular risk
Language English
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Snippet Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging are...
Abstract Arterial stiffness is an established marker of cardiovascular morbidity and mortality and a potential therapeutic target. While hypertension and aging...
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SubjectTerms Anti-Inflammatory Agents - therapeutic use
Arterial stiffness
Biomarkers
Cardiovascular
Cardiovascular Diseases - physiopathology
Cardiovascular risk
Humans
Inflammation
Inflammation - pathology
Pulse wave velocity
Randomized Controlled Trials as Topic
Risk Factors
Vascular Stiffness
Title Inflammation and arterial stiffness in humans
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https://www.clinicalkey.es/playcontent/1-s2.0-S0021915014014117
https://dx.doi.org/10.1016/j.atherosclerosis.2014.09.011
https://www.ncbi.nlm.nih.gov/pubmed/25463062
https://www.proquest.com/docview/1652421394
Volume 237
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