Generation of human islet-specific regulatory T cells by TCR gene transfer

• Published in: Journal of autoimmunity Vol. 79; pp. 63 - 73
• Main Authors: Hull, Caroline M., Nickolay, Lauren E., Estorninho, Megan, Richardson, Max W., Riley, James L., Peakman, Mark, Maher, John, Tree, Timothy I.M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2017
• Subjects: Allergy and Immunology; Animals; Cell Line; Cell therapy; Diabetes; Diabetes Mellitus, Type 1 - genetics; Diabetes Mellitus, Type 1 - immunology; Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - therapy; Disease Models, Animal; Epitopes, T-Lymphocyte - immunology; Gene Order; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors - genetics; Humans; Islets of Langerhans - immunology; Jurkat Cells; Lentivirus - genetics; Mice; Receptors, Antigen, T-Cell - genetics; Regulatory T cells; T-Cell Antigen Receptor Specificity - genetics; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; TCR gene therapy; Transduction, Genetic; Cell therapy; Diabetes; Regulatory T cells; TCR gene therapy

Based on the success in animal models of type 1 diabetes (T1D), clinical trials of adoptive regulatory T cell (Treg) therapy are underway using ex vivo expanded polyclonal Tregs. However, pre-clinical data also demonstrate that islet-specific Tregs are more potent than polyclonal Tregs at reversing...