Multiscale finite element modeling of mechanical strains and fluid flow in osteocyte lacunocanalicular system

• Published in: Bone (New York, N.Y.) Vol. 137; p. 115328
• Main Authors: Ganesh, Thiagarajan, Laughrey, Loretta E., Niroobakhsh, Mohammadmehdi, Lara-Castillo, Nuria
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.08.2020
• Subjects: Finite element model; Fluid flow shear stress; Lacunae; Mechanotransduction; Osteocyte; Perilacunar matrix; Strain; Perilacunar matrix; Lacunae; Finite element model; Mechanotransduction; Fluid flow shear stress; Osteocyte; Strain

Osteocytes form over 90% of the bone cells and are postulated to be mechanosensors responsible for regulating the function of osteoclasts and osteoblasts in bone modeling and remodeling. Physical activity results in mechanical loading on the bones. Osteocytes are thought to be the main mechanosensor...