Genome-wide analysis identifies novel susceptibility loci for myocardial infarction

• Published in: European heart journal Vol. 42; no. 9; pp. 919 - 933
• Main Authors: Hartiala, Jaana A, Han, Yi, Jia, Qiong, Hilser, James R, Huang, Pin, Gukasyan, Janet, Schwartzman, William S, Cai, Zhiheng, Biswas, Subarna, Trégouët, David-Alexandre, Smith, Nicholas L, Seldin, Marcus, Pan, Calvin, Mehrabian, Margarete, Lusis, Aldons J, Bazeley, Peter, Sun, Yan V, Liu, Chang, Quyyumi, Arshed A, Scholz, Markus, Thiery, Joachim, Delgado, Graciela E, Kleber, Marcus E, März, Winfried, Howe, Laurence J, Asselbergs, Folkert W, van Vugt, Marion, Vlachojannis, Georgios J, Patel, Riyaz S, Lyytikäinen, Leo-Pekka, Kähönen, Mika, Lehtimäki, Terho, Nieminen, Tuomo V M, Kuukasjärvi, Pekka, Laurikka, Jari O, Chang, Xuling, Heng, Chew-Kiat, Jiang, Rong, Kraus, William E, Hauser, Elizabeth R, Ferguson, Jane F, Reilly, Muredach P, Ito, Kaoru, Koyama, Satoshi, Kamatani, Yoichiro, Komuro, Issei, Stolze, Lindsey K, Romanoski, Casey E, Khan, Mohammad Daud, Turner, Adam W, Miller, Clint L, Aherrahrou, Redouane, Civelek, Mete, Ma, Lijiang, Björkegren, Johan L M, Kumar, S Ram, Tang, W H Wilson, Hazen, Stanley L, Allayee, Hooman
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.03.2021
• Subjects: Clnical Research; Coronary Artery Disease - genetics; Editor's Choice; Endothelial Cells; Genetic Predisposition to Disease - genetics; Genome-Wide Association Study; Humans; Japan; Myocardial Infarction - genetics; Polymorphism, Single Nucleotide - genetics; Risk Factors; Japan; Myocardial infarction; SLC44A3; Genetic factors; Genome-wide association study; Meta-analysis

While most patients with myocardial infarction (MI) have underlying coronary atherosclerosis, not all patients with coronary artery disease (CAD) develop MI. We sought to address the hypothesis that some of the genetic factors which establish atherosclerosis may be distinct from those that predispos...