Mesenchymal stem cell therapy for acute and chronic pancreatitis

• Published in: Journal of gastroenterology Vol. 53; no. 1; pp. 1 - 5
• Main Authors: Kawakubo, Kazumichi, Ohnishi, Shunsuke, Kuwatani, Masaki, Sakamoto, Naoya
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 2018; Springer; Springer Nature B.V
• Subjects: Abdominal Surgery; Acute Disease; Animals; Cirrhosis; Colorectal Surgery; Gastroenterology; Gastrointestinal diseases; Graft-versus-host reaction; Hepatology; Humans; Inflammation; Inflammation - physiopathology; Inflammation - therapy; Inflammatory bowel diseases; Intestine; Liver cirrhosis; Liver diseases; Medicine; Medicine & Public Health; Mesenchymal Stem Cell Transplantation - methods; Mesenchymal stem cells; Mesenchyme; Pancreatitis; Pancreatitis - physiopathology; Pancreatitis - therapy; Pancreatitis, Chronic - physiopathology; Pancreatitis, Chronic - therapy; Regenerative medicine; Regenerative Medicine - methods; Review; Stem cell transplantation; Stem cells; Surgical Oncology; Transplantation; Acute pancreatitis; Cell therapy; Regenerative medicine; Chronic pancreatitis; Mesenchymal stem cells
• ISSN: 0944-1174; 1435-5922
• DOI: 10.1007/s00535-017-1363-9

Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis by suppressing inflammation. Several studies have investigated the effect of MSC therapy on acute and chronic pancreatitis, but the underlying mechanisms remain unknown. In this review, we summarize the present status of MSC therapy for acute and chronic pancreatitis.