RNA binding motif 4 inhibits the replication of ebolavirus by directly targeting 3′-leader region of genomic RNA

• Published in: Emerging microbes & infections Vol. 13; no. 1; p. 2300762
• Main Authors: Fan, Linjin, Wang, Yulong, Huang, Hongxin, Wang, Zequn, Liang, Chudan, Yang, Xiaofeng, Ye, Pengfei, Lin, Jingyan, Shi, Wendi, Zhou, Yuandong, Yan, Huijun, Long, Zhenyu, Wang, Zhongyi, Liu, Linna, Qian, Jun
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Ltd 01.12.2024; Taylor & Francis; Taylor & Francis Group
• Subjects: 3′-leader region; Antiviral drugs; Ebola; Ebola virus; Ebolavirus - genetics; Genomes; Genomics; HEK293 Cells; Hemorrhagic Fever, Ebola; Humans; RBM4; RNA; RNA binding proteins; RNA-Binding Motifs; RNA-Binding Proteins - genetics; RNA-Binding Proteins - metabolism; RRM1; Virus Replication; Ebola virus; RBM4; RRM1; 3′-leader region; RNA binding proteins

Ebola virus (EBOV) belongs to family possessing single-stranded negative-sense RNA genome, which is a serious threat to human health. Nowadays, no therapeutics have been proven to be successful in efficiently decreasing the mortality rate. RNA binding proteins (RBPs) are reported to participate in m...