Interactions of Oxysterols with Atherosclerosis Biomarkers in Subjects with Moderate Hypercholesterolemia and Effects of a Nutraceutical Combination (Bifidobacterium longum BB536, Red Yeast Rice Extract) (Randomized, Double-Blind, Placebo-Controlled Study)

• Published in: Nutrients Vol. 13; no. 2; p. 427
• Main Authors: Cicolari, Stefania, Pavanello, Chiara, Olmastroni, Elena, Puppo, Marina Del, Bertolotti, Marco, Mombelli, Giuliana, Catapano, Alberico L., Calabresi, Laura, Magni, Paolo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.01.2021; MDPI
• Subjects: Analysis; Atherosclerosis; Bifidobacterium longum; Biological markers; Biomarkers; Cholesterol; Cytochrome; design; Diabetes; dosage; Double-blind studies; Functional foods; Functional foods & nutraceuticals; gas chromatography; Glucose; high density lipoprotein cholesterol; Homeostasis; Hypercholesterolemia; Hypertension; Hypotheses; Insulin resistance; Lipids; lovastatin; low density lipoprotein cholesterol; Low density lipoproteins; mass spectrometry; Metabolism; Metabolites; oxysterols; Physiology; Plasma; red yeast rice; risk; Risk factors; Sample size; Software; Statistical analysis; Type 2 diabetes; visceral fat; United States > US; Italy; 25-OHC; probiotic; oxysterols; cholesterol metabolism; nutraceutical; 24-OHC; cardiovascular risk; monacolin K; 27-OHC; hypercholesterolemia

Background: Oxysterol relationship with cardiovascular (CV) risk factors is poorly explored, especially in moderately hypercholesterolaemic subjects. Moreover, the impact of nutraceuticals controlling hypercholesterolaemia on plasma levels of 24-, 25- and 27-hydroxycholesterol (24-OHC, 25-OHC, 27-OH...