Regulation of the serotonin transporter in the pathogenesis of irritable bowel syndrome

• Published in: World journal of gastroenterology : WJG Vol. 22; no. 36; pp. 8137 - 8148
• Main Authors: Jin, Duo-Chen, Cao, Hai-Long, Xu, Meng-Que, Wang, Si-Nan, Wang, Yu-Ming, Yan, Fang, Wang, Bang-Mao
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 28.09.2016
• Subjects: bowel; Gene Expression Regulation; Humans; Inflammation; Intercellular Signaling Peptides and Proteins - metabolism; Intestinal Mucosa - pathology; Irritable; Irritable Bowel Syndrome - metabolism; Polymorphism, Genetic; Review; RNA, Messenger - metabolism; Serotonin - metabolism; Serotonin Plasma Membrane Transport Proteins - genetics; Serotonin Plasma Membrane Transport Proteins - metabolism; Signal Transduction; syndrome;Serotonin;Serotonin; transporter;Regulation;Therapy; Up-Regulation; Therapy; Regulation; Serotonin transporter; Serotonin; Irritable bowel syndrome

Serotonin(5-HT) and the serotonin transporter(SERT) have earned a tremendous amount of attention regarding the pathogenesis of irritable bowel syndrome(IBS). Considering that enteric 5-HT is responsible for the secretion, motility and perception of the bowel, the involvement of altered enteric 5-HT...