Pipeline for characterizing alternative mechanisms (PCAM) based on bi-clustering to study colorectal cancer heterogeneity

• Published in: Computational and structural biotechnology journal Vol. 21; pp. 2160 - 2171
• Main Authors: Cao, Sha, Chang, Wennan, Wan, Changlin, Lu, Xiaoyu, Dang, Pengtao, Zhou, Xinyu, Zhu, Haiqi, Chen, Jian, Li, Bo, Zang, Yong, Wang, Yijie, Zhang, Chi
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2023; Research Network of Computational and Structural Biotechnology; Elsevier
• Subjects: Alternative drug resistance mechanism; Bi-clustering; biotechnology; Cancer stratification; cancer therapy; Colorectal cancer; colorectal neoplasms; data collection; drug resistance; fluorouracil; Gene expression data; neoplasm progression; transcriptomics; Gene expression data; Cancer stratification; Bi-clustering; Alternative drug resistance mechanism; Colorectal cancer

The cells of colorectal cancer (CRC) in their microenvironment experience constant stress, leading to dysregulated activity in the tumor niche. As a result, cancer cells acquire alternative pathways in response to the changing microenvironment, posing significant challenges for the design of effecti...