TERT promoter mutations and methylation for telomerase activation in urothelial carcinomas: New mechanistic insights and clinical significance

• Published in: Frontiers in immunology Vol. 13; p. 1071390
• Main Authors: Liu, Tiantian, Li, Shihong, Xia, Chuanyou, Xu, Dawei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 12.01.2023
• Subjects: BCG; Carcinoma, Transitional Cell - genetics; Clinical Relevance; Humans; Immunology; immunotherapy; Methylation; Mutation; promoter methylation; promoter mutations; telomerase; Telomerase - genetics; Telomerase - metabolism; TERT; Urinary Bladder Neoplasms - genetics; Urinary Bladder Neoplasms - pathology; telomerase; urothelial carcinoma; TERT; promoter methylation; urothelial cells; BCG; immunotherapy; promoter mutations

Telomerase, an RNA-dependent DNA polymerase synthesizing telomeric TTAGGG sequences, is primarily silent in normal human urothelial cells (NHUCs), but widely activated in urothelial cell-derived carcinomas or urothelial carcinomas (UCs) including UC of the bladder (UCB) and upper track UC (UTUC). Te...