Amazonian malaria: Asymptomatic human reservoirs, diagnostic challenges, environmentally driven changes in mosquito vector populations, and the mandate for sustainable control strategies

• Published in: Acta tropica Vol. 121; no. 3; pp. 281 - 291
• Main Authors: da Silva-Nunes, Mônica, Moreno, Marta, Conn, Jan E., Gamboa, Dionicia, Abeles, Shira, Vinetz, Joseph M., Ferreira, Marcelo U.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2012
• Subjects: Animals; Brazil - epidemiology; Carrier State - diagnosis; Carrier State - parasitology; Communicable Disease Control - methods; Communicable Disease Control - organization & administration; Culicidae; Culicidae - drug effects; Culicidae - parasitology; Culicidae - physiology; Diagnostics; Disease Transmission, Infectious - prevention & control; Disease Vectors; Ecology; Environment; Health Policy - legislation & jurisprudence; Humans; Insecticide-Treated Bednets; issues and policy; Malaria; Malaria - diagnosis; Malaria - prevention & control; Malaria - transmission; Mosquito Control - methods; parasites; Peru - epidemiology; Plasmodium - pathogenicity; Plasmodium vivax; Population Density; public health; Vector biology; villages; Brazil; Amazonia; Caribbean; Peru; Ecology; Malaria; Diagnostics; Vector biology
• ISSN: 0001-706X; 1873-6254
• DOI: 10.1016/j.actatropica.2011.10.001

This article explores potential mechanisms for the persistence of malaria transmission in diverse environmental contexts in the low transmission regions of Amazonian Brazil and Peru. [Display omitted] ► Transmission of malaria continues but is declining in the Americas. ► Mortality rates are low with fewer than 600,000 annual cases regionally. ► Amazonian countries are the main malaria-endemic regions. ► Asymptomatic parasite carriage is common in Amazonia. ► Environmental change affecting vector abundance contributes to malaria transmission. Across the Americas and the Caribbean, nearly 561,000 slide-confirmed malaria infections were reported officially in 2008. The nine Amazonian countries accounted for 89% of these infections; Brazil and Peru alone contributed 56% and 7% of them, respectively. Local populations of the relatively neglected parasite Plasmodium vivax, which currently accounts for 77% of the regional malaria burden, are extremely diverse genetically and geographically structured. At a time when malaria elimination is placed on the public health agenda of several endemic countries, it remains unclear why malaria proved so difficult to control in areas of relatively low levels of transmission such as the Amazon Basin. We hypothesize that asymptomatic parasite carriage and massive environmental changes that affect vector abundance and behavior are major contributors to malaria transmission in epidemiologically diverse areas across the Amazon Basin. Here we review available data supporting this hypothesis and discuss their implications for current and future malaria intervention policies in the region. Given that locally generated scientific evidence is urgently required to support malaria control interventions in Amazonia, we briefly describe the aims of our current field-oriented malaria research in rural villages and gold-mining enclaves in Peru and a recently opened agricultural settlement in Brazil.