Cyclin-Specific Docking Motifs Promote Phosphorylation of Yeast Signaling Proteins by G1/S Cdk Complexes

• Published in: Current biology Vol. 21; no. 19; pp. 1615 - 1623
• Main Authors: Bhaduri, Samyabrata, Pryciak, Peter M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 11.10.2011
• Subjects: Adaptor Proteins, Signal Transducing - metabolism; cell cycle; Cyclin A - metabolism; Cyclin B - metabolism; cyclin-dependent kinase; Cyclin-Dependent Kinases - metabolism; cyclins; eukaryotic cells; G1 Phase; Intracellular Signaling Peptides and Proteins - metabolism; MAP Kinase Kinase Kinases; Phosphorylation; Protein-Serine-Threonine Kinases - metabolism; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae - cytology; Saccharomyces cerevisiae - metabolism; Saccharomyces cerevisiae Proteins - metabolism; Signal Transduction; yeasts

The eukaryotic cell cycle begins with a burst of cyclin-dependent kinase (Cdk) phosphorylation. In budding yeast, several Cdk substrates are preferentially phosphorylated at the G1/S transition rather than later in the cell cycle when Cdk activity levels are high. These early Cdk substrates include...