Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice

• Published in: Acta pharmacologica Sinica Vol. 37; no. 2; pp. 196 - 203
• Main Authors: Zhao, Yang, Dai, Xiao-yan, Zhou, Zhou, Zhao, Ge-xin, Wang, Xian, Xu, Ming-jiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2016; Nature Publishing Group
• Subjects: Animals; Aorta - drug effects; Aorta - metabolism; Aorta - pathology; Apolipoproteins E - genetics; Atherosclerosis - blood; Atherosclerosis - drug therapy; Atherosclerosis - genetics; Atherosclerosis - pathology; Biomedical and Life Sciences; Biomedicine; Dietary Supplements - analysis; Drinking Water - administration & dosage; Drinking Water - analysis; Female; Gene Deletion; Immunology; Inflammation - blood; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - pathology; Internal Medicine; Leucine - administration & dosage; Leucine - analysis; Leucine - therapeutic use; Lipid Metabolism - drug effects; Lipids - blood; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Medical Microbiology; Mice; Mice, Inbred C57BL; Original; original-article; Pharmacology/Toxicology; Vaccine; 制剂; 处方; 药学; 药理; atherosclerosis; ABCG8; ABCG5; apoE null mice; amino acid; inflammation; leucine supplementation; lipid metabolism

Aim： Recent evidence suggests that the essential amino acid leucine may be involved in systemic cholesterol metabolism. In this study, we investigated the effects of leucine supplementation on the development of atherosclerosis in apoE null mice. Methods： ApoE null mice were fed with chow supplement...