A patient-specific approach for quantitative and automatic analysis of computed tomography images in lung disease: Application to COVID-19 patients

• Published in: Physica medica Vol. 82; pp. 28 - 39
• Main Authors: Berta, L., De Mattia, C., Rizzetto, F., Carrazza, S., Colombo, P.E., Fumagalli, R., Langer, T., Lizio, D., Vanzulli, A., Torresin, A.
• Format: Journal Article
• Language: English
• Published: Italy Elsevier Ltd 01.02.2021; Associazione Italiana di Fisica Medica. Published by Elsevier Ltd
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Algorithms; Computed tomography; COVID-19; COVID-19 - diagnostic imaging; Female; Humans; Image analysis; Image Processing, Computer-Assisted; Lung - diagnostic imaging; Lung Diseases - diagnostic imaging; Male; Middle Aged; Original Paper; QCT; Quantitative imaging; Radiomic; Tomography, X-Ray Computed; Young Adult; COVID-19; Radiomic; Image analysis; Quantitative imaging; QCT; Computed tomography

•A new approach has been proposed to overcome limitations of quantitative metrics calculated from lung CT images.•New metrics, derived from physics assumptions and with physiological significance, are introduced.•New metrics show lower dependencies from CT-number and reduced inter and intra patient...