Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis

The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectrosc...

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Published inNeuropsychopharmacology (New York, N.Y.) Vol. 36; no. 9; pp. 1781 - 1791
Main Authors Fuente-Sandoval, Camilo de la, León-Ortiz, Pablo, Favila, Rafael, Stephano, Sylvana, Mamo, David, Ramírez-Bermúdez, Jesús, Graff-Guerrero, Ariel
Format Journal Article
LanguageEnglish
Published Cham Springer International Publishing 01.08.2011
Nature Publishing Group
Subjects
631/378/1457/1936
631/378/1689/1761
631/378/548/1964
692/699/476/1799
Adolescent
Adult
Adult and adolescent clinical studies
Age of Onset
Behavioral Sciences
Biological and medical sciences
Biological Psychology
Caudate Nucleus - metabolism
Caudate Nucleus - pathology
Caudate Nucleus - physiopathology
Disease Progression
Female
Glutamic Acid - metabolism
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Neurosciences
Original
original-article
Pharmacotherapy
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - metabolism
Psychotic Disorders - physiopathology
Risk Factors
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - metabolism
Schizophrenia - physiopathology
Up-Regulation - physiology
Young Adult
associative-striatum
schizophrenia
H-MRS
prodromal
dopamine
glutamate
Human
Dopamine
Central nervous system
Schizophrenia
Prodrome
Basal ganglion
Corpus striatum
Catecholamine
Glutamate
Encephalon
Psychosis
Symptomatology
First episode
Excitatory aminoacid
Neurotransmitter
Online AccessGet full text

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Abstract The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ( 1 H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naïve first- episode psychosis patients (FEP), and (3) 40 age- and sex- matched healthy controls. All subjects underwent a 1 H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.
AbstractList The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ( super(1)H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naive subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naive first- episode psychosis patients (FEP), and (3) 40 age- and sex- matched healthy controls. All subjects underwent a super(1)H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.
The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ( 1 H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naïve first- episode psychosis patients (FEP), and (3) 40 age- and sex- matched healthy controls. All subjects underwent a 1 H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.
The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ((1)H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naïve first- episode psychosis patients (FEP), and (3) 40 age- and sex- matched healthy controls. All subjects underwent a (1)H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ((1)H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naïve first- episode psychosis patients (FEP), and (3) 40 age- and sex- matched healthy controls. All subjects underwent a (1)H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.
The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and may have a role in the neurobiological basis of the disease. The aim of this study was to compare, using proton magnetic resonance spectroscopy ((1)H-MRS), glutamate levels in the precommissural dorsal-caudate (a dopamine-rich region) and the cerebellar cortex (negligible for dopamine) in the following: (1) 18 antipsychotic-naïve subjects with prodromal symptoms and considered to be at ultra high-risk for schizophrenia (UHR), (2) 18 antipsychotic-naïve first- episode psychosis patients (FEP), and (3) 40 age- and sex- matched healthy controls. All subjects underwent a (1)H-MRS study using a 3Tesla scanner. Glutamate levels were quantified and corrected for the proportion of cerebrospinal fluid and percentage of gray matter in the voxel. The UHR and FEP groups showed higher levels of glutamate than controls, without differences between UHR and FEP. In the cerebellum, no differences were seen between the three groups. The higher glutamate level in the precommissural dorsal-caudate and not in the cerebellum of UHR and FEP suggests that a high glutamate level (a) precedes the onset of schizophrenia, and (b) is present in a dopamine-rich region previously implicated in the pathophysiology of schizophrenia.
Author Fuente-Sandoval, Camilo de la
Mamo, David
Stephano, Sylvana
Ramírez-Bermúdez, Jesús
Favila, Rafael
León-Ortiz, Pablo
Graff-Guerrero, Ariel
Author_xml – sequence: 1
  givenname: Camilo de la
  surname: Fuente-Sandoval
  fullname: Fuente-Sandoval, Camilo de la
  organization: Experimental Psychiatry Laboratory, Instituto Nacional de Neurología y Neurocirugía, Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía
– sequence: 2
  givenname: Pablo
  surname: León-Ortiz
  fullname: León-Ortiz, Pablo
  organization: Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía
– sequence: 3
  givenname: Rafael
  surname: Favila
  fullname: Favila, Rafael
  organization: MR Advanced Applications, GE Healthcare
– sequence: 4
  givenname: Sylvana
  surname: Stephano
  fullname: Stephano, Sylvana
  organization: Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía
– sequence: 5
  givenname: David
  surname: Mamo
  fullname: Mamo, David
  organization: Centre for Addiction and Mental Health & Department of Psychiatry, Multimodal Neuroimaging Schizophrenia Group, PET Centre, University of Toronto
– sequence: 6
  givenname: Jesús
  surname: Ramírez-Bermúdez
  fullname: Ramírez-Bermúdez, Jesús
  organization: Neuropsychiatry Department, Instituto Nacional de Neurología y Neurocirugía
– sequence: 7
  givenname: Ariel
  surname: Graff-Guerrero
  fullname: Graff-Guerrero, Ariel
  email: ariel_graff@camh.net
  organization: Centre for Addiction and Mental Health & Department of Psychiatry, Multimodal Neuroimaging Schizophrenia Group, PET Centre, University of Toronto
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24432698$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/21508933$$D View this record in MEDLINE/PubMed
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Issue 9
Keywords associative-striatum
schizophrenia
H-MRS
prodromal
dopamine
glutamate
Human
Dopamine
Central nervous system
Schizophrenia
Prodrome
Basal ganglion
Corpus striatum
Catecholamine
Glutamate
Encephalon
Psychosis
Symptomatology
First episode
Excitatory aminoacid
Neurotransmitter
Language English
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CC BY 4.0
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PublicationSubtitle At the intersection of brain, behavior, and therapeutics
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Snippet The glutamatergic and dopaminergic systems are thought to be involved in the pathophysiology of schizophrenia. Their interaction has been widely documented and...
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SubjectTerms 631/378/1457/1936
631/378/1689/1761
631/378/548/1964
692/699/476/1799
Adolescent
Adult
Adult and adolescent clinical studies
Age of Onset
Behavioral Sciences
Biological and medical sciences
Biological Psychology
Caudate Nucleus - metabolism
Caudate Nucleus - pathology
Caudate Nucleus - physiopathology
Disease Progression
Female
Glutamic Acid - metabolism
Humans
Male
Medical sciences
Medicine
Medicine & Public Health
Neurosciences
Original
original-article
Pharmacotherapy
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Psychosis
Psychotic Disorders - diagnosis
Psychotic Disorders - metabolism
Psychotic Disorders - physiopathology
Risk Factors
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - metabolism
Schizophrenia - physiopathology
Up-Regulation - physiology
Young Adult
Title Higher Levels of Glutamate in the Associative-Striatum of Subjects with Prodromal Symptoms of Schizophrenia and Patients with First-Episode Psychosis
URI https://link.springer.com/article/10.1038/npp.2011.65
https://www.ncbi.nlm.nih.gov/pubmed/21508933
https://www.proquest.com/docview/877546613
https://www.proquest.com/docview/877406341
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https://pubmed.ncbi.nlm.nih.gov/PMC3154101
Volume 36
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