A genetically humanized mouse model for hepatitis C virus infection

• Published in: Nature (London) Vol. 474; no. 7350; pp. 208 - 211
• Main Authors: Dorner, Marcus, Horwitz, Joshua A., Robbins, Justin B., Barry, Walter T., Feng, Qian, Mu, Kathy, Jones, Christopher T., Schoggins, John W., Catanese, Maria Teresa, Burton, Dennis R., Law, Mansun, Rice, Charles M., Ploss, Alexander
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.06.2011; Nature Publishing Group
• Subjects: 631/250/248; 631/250/251/1567; 631/326/596/2555; 692/699/1503/234/2513/1551; Adenoviridae - genetics; Adenoviridae - physiology; Animal models; Animals; Antibodies, Blocking - immunology; Antigens, CD - genetics; Antigens, CD - metabolism; Biological and medical sciences; Cells, Cultured; Claudin-1; Disease Models, Animal; Genetics; Genomes; Genotype; Hepacivirus - genetics; Hepacivirus - metabolism; Hepacivirus - physiology; Hepatitis; Hepatitis C - genetics; Hepatitis C - virology; Hepatitis C virus; Hepatocytes - cytology; Hepatocytes - metabolism; Hepatocytes - virology; Human factors; Human viral diseases; Humanities and Social Sciences; Humans; Immunization; Immunization, Passive; Infectious diseases; letter; Medical sciences; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; multidisciplinary; Proteins; Receptors, Virus - genetics; Receptors, Virus - metabolism; Rodents; Scavenger Receptors, Class B - genetics; Scavenger Receptors, Class B - metabolism; Science; Science (multidisciplinary); Studies; Tetraspanin 28; Transfection; Vaccinia virus; Viral diseases; Viral hepatitis; Viral Tropism; Animal model; Pathogenesis; Recombinant virus; Hepatic disease; Heterotransplantation; Prevention; Life cycle; Hepatocyte; Antiviral; Vector; Humoral immunity; Viral hepatitis C; Human; Chordopoxvirinae; Orthopoxvirus; Rodentia; Vaccine; Gene expression; Infection; Virus; Vaccinia virus; Immunoprophylaxis; In vivo; Vertebrata; Mammalia; Treatment; Mouse; Poxviridae; Viral disease; Animal; Digestive diseases; Flaviviridae; Hepatitis C virus; Hepacivirus; Passive immunization

A mouse model for hepatitis C infection The development of therapies for hepatitis C virus (HCV) infection has been hampered by the lack of a small-animal model of the disease. Now Alexander Ploss and colleagues describe the first immunocompetent rodent model for hepatitis C virus infection, using a...