Envelope proteins of two HIV-1 clades induced different epitope-specific antibody response

• Published in: Vaccine Vol. 36; no. 12; pp. 1627 - 1636
• Main Authors: Shrivastava, Tripti, Samal, Sweety, Tyagi, Ashish K., Goswami, Sandeep, Kumar, Naresh, Ozorowski, Gabriel, Ward, Andrew B., Chakrabarti, Bimal K.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 14.03.2018; Elsevier Limited
• Subjects: Animals; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibody Formation; Antibody response; Antibody Specificity - immunology; Antigens; Binding sites; CD4 antigen; Cloning; Deoxyribonucleic acid; DNA; env Gene Products, Human Immunodeficiency Virus - genetics; env Gene Products, Human Immunodeficiency Virus - immunology; Epitope Mapping; Epitopes - chemistry; Epitopes - immunology; Gene Expression; Genotype; gp140-foldon trimer; HIV; HIV Antibodies - blood; HIV Antibodies - immunology; HIV Infections - immunology; HIV Infections - virology; HIV-1 - classification; HIV-1 - genetics; HIV-1 - immunology; HIV-1 Indian clade C; Human immunodeficiency virus; Humans; Immune response; Immune Sera - immunology; Immune system; Immunization; Immunoglobulins; Low level; Monovalent/bivalent immunization; Neutralization Tests; Neutralizing; Neutralizing antibody; Peptides; Plasmids; Protein Binding - immunology; Protein Multimerization; Proteins; Rabbits; Recombinant Proteins; Standard deviation; Vaccine; Vaccines; Viral envelope proteins; Virology; Washington DC; United States > US; Africa; India; Vaccine; HIV-1 Indian clade C; gp140-foldon trimer; Monovalent/bivalent immunization; Neutralizing antibody

•More than 50% of global HIV-1 infected population is infected with clade C virus.•The efficiently cleaved 4-2.J41 Env selectively binds to neutralizing antibodies.•The soluble 4-2.J41-gp140-foldon proteins bind to broadly neutralizing antibodies.•DNA prime/protein boost with clade C, 4-2.J41 Env el...