Control of Tumorigenesis and Chemoresistance by the DEK Oncogene

• Published in: Clinical cancer research Vol. 16; no. 11; pp. 2932 - 2938
• Main Authors: Riveiro-Falkenbach, Erica, Soengas, María S.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.06.2010
• Subjects: Antineoplastic agents; Biological and medical sciences; Cell Transformation, Neoplastic - genetics; Chromatin - metabolism; Chromosomal Proteins, Non-Histone - genetics; Drug Delivery Systems; Drug Resistance, Neoplasm; Gene Expression Regulation; Humans; Medical sciences; Neoplasms - genetics; Oncogene Proteins - genetics; Pharmacology. Drug treatments; Poly-ADP-Ribose Binding Proteins; Protein Processing, Post-Translational; Proto-Oncogene Mas; Proto-Oncogenes; Control; Treatment resistance; Tumorigenicity; Onc gene; Carcinogenesis

Slight modifications of chromatin dynamics can translate into small- and large-scale changes in DNA replication and DNA repair. Similarly, promoter usage and accessibility are tightly dependent on chromatin architecture. Consequently, it is perhaps not surprising that factors controlling chromatin o...