Efficacy of Low-Carbohydrate Ketogenic Diet as an Adjuvant Cancer Therapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

• Published in: Nutrients Vol. 13; no. 5; p. 1388
• Main Authors: Yang, Ya-Feng, Mattamel, Preety Babychen, Joseph, Tanya, Huang, Jian, Chen, Qian, Akinwunmi, Babatunde O., Zhang, Casper J. P., Ming, Wai-Kit
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.04.2021; MDPI
• Subjects: Adjuvant treatment; Adjuvants; Analysis; Antimitotic agents; Antineoplastic agents; Bias; Biomarkers; Biomarkers, Tumor - metabolism; Blood cholesterol; blood glucose; Blood Glucose - metabolism; Blood sugar; Body Weight; Brain cancer; Cancer; Cancer therapies; cancer therapy; Carbohydrates; Case-Control Studies; Chemotherapy; Cholesterol; Clinical trials; Diabetes; Diet; Diet, Carbohydrate-Restricted - adverse effects; Diet, Ketogenic - adverse effects; Fasting; Fasting - blood; Glucose; Health aspects; high density lipoprotein cholesterol; Humans; Immunotherapy; Insulin; Insulin - blood; ketogenic diet; Ketosis; lipid composition; Lipids; Lipids - blood; low density lipoprotein cholesterol; Low density lipoproteins; Meta-analysis; neoplasms; Neoplasms - blood; Neoplasms - diet therapy; nutritional intervention; Odds Ratio; Patient Satisfaction; Performance evaluation; Proteins; Radiation therapy; Randomized Controlled Trials as Topic; sample size; Standard deviation; Statistical analysis; Systematic review; Treatment Outcome; triacylglycerols; low-carbohydrate diet; adjuvant cancer therapy; cancer; randomized controlled trials; ketogenic diet

Background: The role of low-carbohydrate ketogenic diet (LCKD) as an adjuvant therapy in antitumor treatment is not well established. This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to investigate the efficacy of LCKD as an adjuvant therapy in antitumor...