Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4′-Fluorouridine - Yin, Peiqi; Sobolik, Elizabeth B.; May, Nicholas A.; Wang, Sainan; Fayed, Atef; Vyshenska, Dariia; Drobish, Adam M.; Parks, M. Guston; Lello, Laura Sandra; Merits, Andres; Morrison, Thomas E.; Greninger, Alexander L.; et al. (PLoS pathogens, 2025)
Keywords: Animals; Antiviral agents; Antiviral Agents - pharmacology; Biology and life sciences; Chikungunya Fever - drug therapy; Chikungunya Fever - virology; Chikungunya virus; Chikungunya virus - drug effects; Chikungunya virus - genetics; Control; Dosage and administration; Drug Resistance, Viral - genetics; Genetic aspects; Humans; Medical research; Medicine and Health Sciences; Medicine, Experimental; Mice; Mutation; Physiological aspects; Viral genetics; Viral Nonstructural Proteins - genetics; Viral proteins; Virus Replication - drug effects; Virus Replication - genetics; United States