Gene Expression Profiling of Multiple Histone Deacetylases (HDAC) and Its Correlation with NRF2-Mediated Redox Regulation in the Pathogenesis of Diabetic Foot Ulcers

• Published in: Biomolecules (Basel, Switzerland) Vol. 10; no. 10; p. 1466
• Main Authors: Teena, Rajan, Dhamodharan, Umapathy, Ali, Daoud, Rajesh, Kesavan, Ramkumar, Kunka Mohanram
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.10.2020; MDPI
• Subjects: Alzheimer's disease; Angiogenesis; Blood pressure; Cancer; Cholesterol; Diabetes; Diabetes mellitus (non-insulin dependent); Diabetic foot; diabetic wounds; DNA methylation; Epigenetics; Feet; Foot diseases; Gene expression; Genetic aspects; Glucose; HDAC2 protein; HDACs; Health aspects; Histone deacetylase; Histones; Homeostasis; Inflammation; Interleukin 10; Interleukin 6; Investigations; Leucine zipper proteins; Nrf2; Oxidative stress; Pathogenesis; Peripheral neuropathy; Plasma; Proteins; SIRT1 protein; sirtuins; Tumor necrosis factor-α; Ulcers; India; United States > US; HDACs; Nrf2; angiogenesis; sirtuins; epigenetics; diabetic wounds

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a protein of the leucine zipper family, which mitigates inflammation and employs cytoprotective effects. Attempting to unravel the epigenetic regulation of type 2 diabetes mellitus (T2DM) and diabetic foot ulcer (DFU), we profiled the expression...