Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression

• Published in: The Journal of biological chemistry Vol. 269; no. 31; pp. 20119 - 20125
• Main Authors: Sylvester, S L, ap Rhys, C M, Luethy-Martindale, J D, Holbrook, N J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 05.08.1994
• Subjects: Acute-Phase Reaction - genetics; Animals; Base Sequence; Biological and medical sciences; CCAAT-Enhancer-Binding Proteins; DNA-Binding Proteins - metabolism; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Humans; Inflammation; Lipopolysaccharides - pharmacology; Liver - metabolism; Lung - metabolism; Male; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Nuclear Proteins - metabolism; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Protein Biosynthesis; Proteins - genetics; Rats; Rats, Inbred F344; RNA, Messenger - biosynthesis; Transcription Factor CHOP; Transcription Factors; Transcription. Transcription factor. Splicing. Rna processing; Transcriptional Activation; Tumor Cells, Cultured; Vertebrata; Acute phase protein; Regulation(control); Mammalia; Transcription; Rat; Rodentia; Footprinting technique; Inflammation; Gel retardation technique; Transcription factor; Transcription factor C/EBP

CCAAT/enhancer-binding proteins (C/EBPs) comprise a homologous group of transcriptional regulators that control liver and fat differentiation and are involved in regulating the expression of acute phase reactants during the host response to inflammation. GADD153, a unique member of the C/EBP family,...