Flagellin-specific human CAR Tregs for immune regulation in IBD

• Published in: Journal of autoimmunity Vol. 134; p. 102961
• Main Authors: Boardman, Dominic A., Wong, May Q., Rees, William D., Wu, Dan, Himmel, Megan E., Orban, Paul C., Vent-Schmidt, Jens, Zachos, Nicholas C., Steiner, Theodore S., Levings, Megan K.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.01.2023
• Subjects: Animals; Chimeric antigen receptor; Flagellin; Flagellin - metabolism; Humans; Inflammatory bowel disease; Inflammatory Bowel Diseases - metabolism; Inflammatory Bowel Diseases - therapy; Mice; Receptors, Chimeric Antigen - genetics; Receptors, Chimeric Antigen - metabolism; Recombinant Proteins - metabolism; Regulatory T cell; T-Lymphocytes, Regulatory; Treg therapy; Inflammatory bowel disease; Treg therapy; Flagellin; Chimeric antigen receptor; Regulatory T cell

Regulatory T cell (Treg) therapy is a promising strategy to treat inflammatory bowel disease (IBD). Data from animal models has shown that Tregs specific for intestinal antigens are more potent than polyclonal Tregs at inhibiting colitis. Flagellins, the major structural proteins of bacterial flagel...