New role of PCSK9 in atherosclerotic inflammation promotion involving the TLR4/NF-κB pathway - Tang, Zhi-Han; Peng, Juan; Ren, Zhong; Yang, Jing; Li, Ting-Ting; Li, Tao-Hua; Wang, Zuo; Wei, Dang-Heng; Liu, Lu-Shan; Zheng, Xi-Long; Jiang, Zhi-Sheng (Atherosclerosis, 2017)
Keywords: Animals; Aorta - enzymology; Aorta - pathology; Aortic Diseases - enzymology; Aortic Diseases - genetics; Aortic Diseases - pathology; Atherosclerosis; Atherosclerosis - enzymology; Atherosclerosis - genetics; Atherosclerosis - pathology; Cardiovascular; Disease Models, Animal; Genetic Predisposition to Disease; Inflammation; Inflammation - enzymology; Inflammation - genetics; Inflammation - pathology; Inflammation Mediators - metabolism; Lipoproteins, LDL - pharmacology; Macrophage; Macrophages - drug effects; Macrophages - enzymology; Male; Mice; Mice, Knockout, ApoE; NF-kappa B - metabolism; PCSK9; Phenotype; Plaque, Atherosclerotic; Proprotein Convertase 9 - genetics; Proprotein Convertase 9 - metabolism; RAW 264.7 Cells; RNA Interference; RNA, Small Interfering - genetics; RNA, Small Interfering - metabolism; Signal Transduction; TLR4/ /NF-κB; Toll-Like Receptor 4 - metabolism; PCSK9; Inflammation; TLR4/ /NF-κB; Atherosclerosis; Macrophage