Gene expression profiling of bone marrow mesenchymal stem cells from Osteogenesis Imperfecta patients during osteoblast differentiation

• Published in: European journal of medical genetics Vol. 60; no. 6; pp. 326 - 334
• Main Authors: Kaneto, Carla Martins, Pereira Lima, Patrícia S., Prata, Karen Lima, dos Santos, Jane Lima, de Pina Neto, João Monteiro, Panepucci, Rodrigo Alexandre, Noushmehr, Houtan, Covas, Dimas Tadeu, de Paula, Francisco José Alburquerque, Silva, Wilson Araújo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Masson SAS 01.06.2017
• Subjects: Adolescent; Adult; Bone marrow mesenchymal stem cell; Case-Control Studies; Cells, Cultured; Female; Gene expression; Gene Expression Profiling; Humans; Male; Medical Education; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Osteoblasts - cytology; Osteoblasts - metabolism; Osteogenesis Imperfecta; Osteogenesis Imperfecta - genetics; Osteogenesis Imperfecta - metabolism; Osteogenesis Imperfecta - pathology; Osteogenic differentiation; Gene expression; Osteogenic differentiation; Bone marrow mesenchymal stem cell; Osteogenesis Imperfecta

Mesenchymal stem cells (MSCs) are precursors present in adult bone marrow that are able to differentiate into osteoblasts, adipocytes and chondroblasts that have gained great importance as a source for cell therapy. Recently, a number of studies involving the analysis of gene expression of undiffere...