Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children

• Published in: Journal of allergy and clinical immunology Vol. 145; no. 4; pp. 1219 - 1230
• Main Authors: Do, Anh N., Watson, Corey T., Cohain, Ariella T., Griffin, Robert S., Grishin, Alexander, Wood, Robert A., Wesley Burks, A., Jones, Stacie M., Scurlock, Amy, Leung, Donald Y.M., Sampson, Hugh A., Sicherer, Scott H., Sharp, Andrew J., Schadt, Eric E., Bunyavanich, Supinda
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2020
• Subjects: Adolescent; Allergens - immunology; Anaphylaxis - genetics; Arachis - immunology; causal mediation; CD4-Positive T-Lymphocytes - physiology; Child; Cohort Studies; Disease Progression; DNA Methylation; Epigenesis, Genetic; epigenome; Female; Food allergy; Gene Regulatory Networks; Humans; Immunity - genetics; Immunization; integrated network; Male; peanut allergy; Peanut Hypersensitivity - genetics; reaction severity; Transcriptome; Food allergy; sIgE; epigenome; transcriptome; GO; reaction severity; RNAseq; peanut allergy; NF-κB; FDR; SPT; eCpG; causal mediation; integrated network

Unexpected allergic reactions to peanut are the most common cause of fatal food-related anaphylaxis. Mechanisms underlying the variable severity of peanut-allergic reactions remain unclear. We sought to expand mechanistic understanding of reaction severity in peanut allergy. We performed an integrat...