Ventilation defects on hyperpolarized helium-3 MRI in asthma are predictive of 2-year exacerbation frequency

• Published in: Journal of allergy and clinical immunology Vol. 146; no. 4; pp. 831 - 839.e6
• Main Authors: Mummy, David G., Carey, Katherine J., Evans, Michael D., Denlinger, Loren C., Schiebler, Mark L., Sorkness, Ronald L., Jarjour, Nizar N., Fain, Sean B.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2020
• Subjects: Adult; airway obstruction; Asthma; Asthma - diagnostic imaging; Asthma - physiopathology; Asthma - therapy; Biomarkers; Disease Progression; Female; Follow-Up Studies; functional; Helium; Humans; Isotopes; Lung - diagnostic imaging; Lung - physiopathology; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Middle Aged; patient outcomes assessment; Prognosis; Respiratory Function Tests; Severity of Illness Index; Young Adult; Q1; Feno; magnetic resonance imaging; functional; Q3; VDP; MRI; IRR; 3He MRI; Asthma; ACQ; SARP III; airway obstruction; CT; GERD; ACT; FVC; patient outcomes assessment; ICS; OCS; BMI; ED; UW-Madison

There is an unmet need for an objective biomarker to predict asthma exacerbations. Our aim was to assess the ventilation defect percent (VDP) on hyperpolarized helium-3 magnetic resonance imaging as a predictor of exacerbation frequency following imaging. Subjects underwent hyperpolarized helium-3 a...