Reactive oxygen: A novel antimicrobial mechanism for targeting biofilm-associated infection

• Published in: Journal of Global Antimicrobial Resistance Vol. 8; pp. 186 - 191
• Main Authors: Dryden, Matthew S., Cooke, Jonathan, Salib, Rami J., Holding, Rebecca E., Biggs, Timothy, Salamat, Ali A., Allan, Raymond N., Newby, Rachel S., Halstead, Fenella, Oppenheim, Beryl, Hall, Thomas, Cox, Sophie C., Grover, Liam M., Al-hindi, Zain, Novak-Frazer, Lilyann, Richardson, Malcolm D.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.03.2017
• Subjects: Administration, Topical; Animals; Anti-Infective Agents, Local - therapeutic use; Bacteria - drug effects; Bacterial Infections - drug therapy; Biofilm; Biofilms - drug effects; Chronic wounds; Cystic fibrosis; Drug Evaluation, Preclinical; Fungi - drug effects; Humans; Infectious Disease; Prosthetic device infection; Reactive oxygen species; Reactive Oxygen Species - therapeutic use; Wound Infection - drug therapy; Biofilm; Chronic wounds; Cystic fibrosis; Reactive oxygen species; Prosthetic device infection

•Reactive oxygen species (ROS) delivered by engineered honey or gel.•Novel antimicrobial with activity against all bacteria as well as antifungal and antiviral activity.•Topical treatment with antibiofilm activity.•Therapeutic implications for wound healing and possibly mucosal infection in respirat...