Plasmalogens of high-density lipoproteins (HDL) are associated with coronary artery disease and anti-apoptotic activity of HDL

• Published in: Atherosclerosis Vol. 241; no. 2; pp. 539 - 546
• Main Authors: Sutter, Iryna, Velagapudi, Srividya, Othman, Alaa, Riwanto, Meliana, Manz, Jasmin, Rohrer, Lucia, Rentsch, Katharina, Hornemann, Thorsten, Landmesser, Ulf, von Eckardstein, Arnold
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.08.2015
• Subjects: Acute Coronary Syndrome - blood; Adult; Aged; Apolipoprotein A-I - metabolism; Apoptosis; Cardiovascular; Case-Control Studies; Chromatography, Liquid; Coronary artery disease; Coronary Artery Disease - blood; Discriminant Analysis; Endothelial cells; Endothelial Cells - cytology; Female; HDL; Humans; Least-Squares Analysis; Lipidomics; Lipids; Lipoproteins, HDL - chemistry; Lysophosphatidylcholines - chemistry; Lysophospholipids - chemistry; Male; Mass Spectrometry; Middle Aged; Phosphatidylcholines - chemistry; Plasmalogens; Plasmalogens - chemistry; Sphingomyelins - chemistry; Sphingosine - analogs & derivatives; Sphingosine - chemistry; Sphingosine-1-phosphate; HDL; Sphingosine-1-phosphate; Lipidomics; Plasmalogens; Coronary artery disease; Endothelial cells; Apoptosis

Low high-density lipoprotein (HDL) cholesterol and loss of atheroprotective functions of HDL are associated with coronary artery disease (CAD). Here, we investigated the associations of HDL phospholipids with acute and stable CAD as well as with the anti-apoptotic activity of HDL. 49 species of phos...