Novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle

• Published in: Emerging microbes & infections Vol. 13; no. 1; p. 2368217
• Main Authors: Wang, Yulong, Fan, Linjin, Ye, Pengfei, Wang, Zequn, Liang, Chudan, Liu, Quan, Yang, Xiaofeng, Long, Zhenyu, Shi, Wendi, Zhou, Yuandong, Lin, Jingyan, Yan, Huijun, Huang, Hongxin, Liu, Linna, Qian, Jun
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis Ltd 01.12.2024; Taylor & Francis; Taylor & Francis Group
• Subjects: Antiviral drugs; Epidemics; Genomes; high-throughput screening; Infections; Infectious diseases; Laboratories; Molecular biology; neutralizing antibodies; Nipah virus; Pathogens; Plasmids; Proteins; Public health; RNA polymerase; trVLP; Vaccines; Viruses; neutralising antibodies; antiviral drugs; Nipah virus; trVLP; high throughput screening
• ISSN: 2222-1751; 2222-1751
• DOI: 10.1080/22221751.2024.2368217

Nipah virus (NiV), a highly pathogenic Henipavirus in humans, has been responsible for annual outbreaks in recent years. Experiments revolving live NiV are highly restricted to biosafety level 4 (BSL-4) laboratories, which impedes NiV research. In this study, we developed a transcription and replica...