Florbetapir F18 PET Amyloid Neuroimaging and Characteristics in Patients With Mild and Moderate Alzheimer Dementia

• Published in: Psychosomatics (Washington, D.C.) Vol. 57; no. 2; pp. 208 - 216
• Main Authors: Degenhardt, Elisabeth K., Witte, Michael M., Case, Michael G., Yu, Peng, Henley, David B., Hochstetler, Helen M., D’Souza, Deborah N., Trzepacz, Paula T.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.03.2016
• Subjects: Aged; Alzheimer Disease - diagnostic imaging; Amyloid - metabolism; Aniline Compounds; Autopsy; Brain - diagnostic imaging; Ethylene Glycols; Female; Fluorodeoxyglucose F18; Humans; Internal Medicine; Male; Neuroimaging; Positron-Emission Tomography; Psychiatry; Reproducibility of Results; Sensitivity and Specificity; Severity of Illness Index

Clinical diagnosis of Alzheimer disease (AD) is challenging, with a 70.9%–87.3% sensitivity and 44.3%–70.8% specificity, compared with autopsy diagnosis. Florbetapir F18 positron emission tomography (FBP-PET) estimates beta-amyloid plaque density antemortem. Of 2052 patients (≥55 years old) clinical...