Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model

• Published in: Journal of hepatology Vol. 52; no. 6; pp. 903 - 912
• Main Authors: Shindo, Nobuyasu, Fujisawa, Tomomi, Sugimoto, Ken, Nojima, Koji, Oze-Fukai, Aya, Yoshikawa, Yuki, Wang, Xiang, Yasuda, Osamu, Ikegami, Hiroshi, Rakugi, Hiromi
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier B.V 01.06.2010; Elsevier
• Subjects: Animals; Biological and medical sciences; Blood Glucose - metabolism; Carrier Proteins - genetics; Carrier Proteins - metabolism; Cholesterol, VLDL - blood; Diabetes. Impaired glucose tolerance; Disease Models, Animal; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Fatty Liver - metabolism; Fatty Liver - pathology; Fatty Liver - physiopathology; Gastroenterology and Hepatology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Expression - physiology; Glucose intolerance; Glucose Intolerance - metabolism; Glucose Intolerance - pathology; Glucose Intolerance - physiopathology; Insulin - blood; Insulin resistance; Insulin Resistance - physiology; Lipid Metabolism - genetics; Liver - metabolism; Liver - pathology; Liver Cirrhosis - metabolism; Liver Cirrhosis - pathology; Liver Cirrhosis - physiopathology; Male; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microsomal triglyceride transfer protein; Microsomes, Liver - metabolism; Microsomes, Liver - pathology; Nonalcoholic steatohepatitis; Phenotype; Spontaneous model; Transfection; Triglycerides - metabolism; triglyceride; NAFLD; MCP-1; Spontaneous model; Glucose intolerance; Irs1; MTP; alanine aminotransferase; monocyte chemoattractant protein-1; microsomal triglyceride transfer protein; ALT; Irs2; F4/80; nonalcoholic steatohepatitis; B6 mouse; FLS mouse; Fatty Liver Shionogi mouse; VLDL; gamma-glutamyltransferase; ApoB; HPLC; cell surface glycoprotein F4/80; BMI; AST; body mass index; homeostasis model assessment ratio; NASH; aspartate aminotransferase; C57BL/6 mouse; intraperitoneal glucose tolerance test; nonalcoholic fatty liver disease; high performance liquid chromatography; insulin receptor substrate 2; TG; insulin receptor substrate 1; TNF-α; GGT; tumor necrosis factor-α; Insulin resistance; very low density lipoprotein; HOMA-R; ipGTT; apolipoprotein B; Nonalcoholic steatohepatitis; Microsomal triglyceride transfer protein; Endocrinopathy; Spontaneous; Rodentia; Metabolic diseases; Triglyceride; Protein; Target tissue resistance; Vertebrata; Mammalia; Mouse; Animal; Gastroenterology; Models; Impaired glucose tolerance

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is currently recognized as a global health issue and encompasses a wide spectrum of entities, ranging from simple hepatic steatosis to nonalcoholic steatohepatitis (NASH). The lack of a spontaneous animal model of NASH, however, has hamp...